For research use only. Not for therapeutic Use.
Cefonicid Sodium（Cat No.:I004310）is a second-generation cephalosporin antibiotic known for its broad-spectrum activity against gram-positive and some gram-negative bacteria. It inhibits bacterial cell wall synthesis, making it effective in treating infections caused by Staphylococcus and Streptococcus species. In research, Cefonicid Sodium is utilized for studies in pharmacokinetics, antibiotic resistance, and bacterial infection models. Its high stability and solubility enhance its suitability for in vitro and in vivo testing, supporting the development of new antimicrobial strategies and advancing our understanding of cephalosporin efficacy and resistance.
| Catalog Number | I004310 |
| CAS Number | 61270-78-8 |
| Synonyms | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt |
| Molecular Formula | C18H16N6O8S3 • 2Na |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO: 16mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | disodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| InChI | InChI=1S/C18H18N6O8S3.2Na/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32;;/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32);;/q;2*+1/p-2/t11-,13-,16-;;/m1../s1 |
| InChIKey | NAXFZVGOZUWLEP-RFXDPDBWSA-L |
| SMILES | C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)O)C(=O)[O-])CSC4=NN=NN4CS(=O)(=O)[O-].[Na+].[Na+] |
| Reference | </br>1:Compatibility of clindamycin phosphate with aztreonam in polypropylene syringes and with cefoperazone sodium, cefonicid sodium, and cefuroxime sodium in partial-fill glass bottles. Marble DA, Bosso JA, Townsend RJ.Drug Intell Clin Pharm. 1988 Jan;22(1):54-7. PMID: 3349921 </br>2:Cost-effectiveness of cefonicid sodium versus cefoxitin sodium for the prevention of postoperative infections after nonelective cesarean section. Briggs GG, Moore BR, Bahado-Singh R, Lange S, Bogh P, Garite TJ.Clin Pharm. 1987 Sep;6(9):718-21. No abstract available. PMID: 3119278 </br>3:Stability of cefonicid sodium in infusion fluids. Wong WW, Maderich AB, Polli GP, Ravin LJ.Am J Hosp Pharm. 1985 Sep;42(9):1980-3. PMID: 4050816 </br>4:Cefonicid sodium (Monocid). [No authors listed]Med Lett Drugs Ther. 1984 Aug 3;26(667):71-2. No abstract available. PMID: 6379400 |
