Cefoperazone sodium salt

• CAT Number: I004369
• CAS Number: 62893-20-3
• Molecular Formula: C25H26N9O8S2 • Na
• Molecular Weight: 667.70
• Purity: ≥95%
• Synonyms: Cefoneg;Cefosint;CP 52,640-2;Perocef
• Target: Antibacterial
• Solubility: 50 mg/mL in H2O
• Storage: Store at -20°C
• IUPAC Name: sodium;(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
• InChIKey: NCFTXMQPRQZFMZ-WERGMSTESA-M
• SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)[O-].[Na+]

Cefoperazone sodium salt（Cat No.:I004369）is a third-generation cephalosporin antibiotic used to treat a broad range of bacterial infections, particularly those caused by Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell death. Cefoperazone is especially effective for infections in the respiratory, urinary, and biliary tracts, as well as for septicemia and intra-abdominal infections. Its sodium salt form enhances solubility and stability, making it suitable for intravenous administration in hospital settings. Often combined with sulbactam to combat beta-lactamase-producing bacteria, it is a key antibiotic in treating resistant infections.

Reference

1:Przegl Lek. 1987;44(3):355-8. [Clinical evaluation of Cefobid (sodium salt of cefoperazone) in the treatment of the most frequently occurring forms of peritonitis].Kulig J,Legutko J,Lukasiewicz J,Gil T, PMID: 3615938