Cefoselis

For research use only. Not for therapeutic Use.

  • CAT Number: I000887
  • CAS Number: 122841-10-5
  • Molecular Formula: C19H22N8O6S2
  • Molecular Weight: 522.56
  • Purity: ≥95%
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Cefoselis(Cat No.:I000887)is a broad-spectrum cephalosporin antibiotic used to treat bacterial infections. It works by inhibiting bacterial cell wall synthesis, causing cell lysis and death. Cefoselis is effective against both Gram-positive and Gram-negative bacteria, making it useful in managing infections such as pneumonia, skin infections, and urinary tract infections. As a semi-synthetic cephalosporin, it has improved resistance to β-lactamase enzymes compared to earlier generations. Cefoselis is commonly administered intravenously or intramuscularly in clinical settings, with dosing determined by the infection type and patient condition.


Catalog Number I000887
CAS Number 122841-10-5
Synonyms

(6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Molecular Formula C19H22N8O6S2
Purity ≥95%
Target Antibiotic
Solubility 10 mM in DMSO
Storage Store at -20C
IUPAC Name (6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChI InChI=1S/C19H22N8O6S2/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28/h2-3,8,13,17,20,28H,4-7H2,1H3,(H4,21,22,23,29,31,32)/b24-12-/t13-,17-/m1/s1
InChIKey BHXLLRXDAYEMPP-SBGRAJFYSA-N
SMILES CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=C(N4CCO)N)C(=O)[O-]
Reference

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<br>[1]. ZHU, D., et al., In vitro activities of cefoselis compared to β-lactams and other antibacterial agents aganst gram-positive and gram-negative clinical isolates. Chinese Journal of Infection and Chemotherapy, 2011. 4: p. 002.
<br>[2]. King, A., L. Bethune, and I. Phillips, The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin. Clin Microbiol Infect, 1995. 1(1): p. 13-17.
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