Cefotaxime Sodium

• CAT Number: A000095
• CAS Number: 64485-93-4
• Molecular Formula: C16H16N5O7S2 ? Na
• Molecular Weight: 477.50
• Purity: ≥95%
• Target: Beta-lactamase
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
• InChIKey: AZZMGZXNTDTSME-JUZDKLSSSA-M
• SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]

Cefotaxime Sodium（Cat No.:A000095）is a third-generation cephalosporin antibiotic used to treat a broad range of bacterial infections, including respiratory, urinary tract, and skin infections. It works by inhibiting bacterial cell wall synthesis, making it effective against both Gram-positive and Gram-negative organisms. The sodium salt form enhances its solubility and facilitates intravenous or intramuscular administration, ensuring rapid therapeutic action. Cefotaxime Sodium is particularly valuable in hospital settings for treating severe infections, including meningitis and septicemia, and is a key agent in combating resistant bacterial strains in clinical research.

Reference

1: Sun H, Cui X, Liu B, Zhang J. Relationship between the color stability and
impurity profile of cefotaxime sodium. J Chromatogr B Analyt Technol Biomed Life
Sci. 2017 Sep 15;1063:235-244. doi: 10.1016/j.jchromb.2017.08.043. Epub 2017 Sep
7. PubMed PMID: 28890363.

2: Al-Nimry SS, Alkhamis KA, Alzarieni KZ. The Effect of Specific Surface Area of
Chitin-Metal Silicate Coprocessed Excipient on the Chemical Decomposition of
Cefotaxime Sodium. J Pharm Sci. 2017 Feb;106(2):570-578. doi:
10.1016/j.xphs.2016.10.012. Epub 2016 Nov 23. PubMed PMID: 27887722.

3: Zakaria AS, Afifi SA, Elkhodairy KA. Newly Developed Topical Cefotaxime Sodium
Hydrogels: Antibacterial Activity and In Vivo Evaluation. Biomed Res Int.
2016;2016:6525163. doi: 10.1155/2016/6525163. Epub 2016 May 24. PubMed PMID:
27314033; PubMed Central PMCID: PMC4895050.

4: Ilem-Ozdemir D, Asikoglu M, Ozkilic H, Yilmaz F, Hosgor-Limoncu M, Ayhan S.
Gamma scintigraphy and biodistribution of (99m)Tc-cefotaxime sodium in
preclinical models of bacterial infection and sterile inflammation. J Labelled
Comp Radiopharm. 2016 Mar;59(3):109-16. doi: 10.1002/jlcr.3374. Epub 2016 Feb 16.
PubMed PMID: 26880705.

5: Türkeş C, Söyüt H, Beydemir Ş. Human serum paraoxonase-1 (hPON1): in vitro
inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate,
cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium. J Enzyme Inhib
Med Chem. 2015;30(4):622-8. doi: 10.3109/14756366.2014.959511. Epub 2014 Dec 18.
PubMed PMID: 25519764.

6: Sharma R, Choudhary S, Kishore N. Insights into the binding of the drugs
diclofenac sodium and cefotaxime sodium to serum albumin: calorimetry and
spectroscopy. Eur J Pharm Sci. 2012 Aug 15;46(5):435-45. doi:
10.1016/j.ejps.2012.03.007. Epub 2012 Mar 29. PubMed PMID: 22483968.

7: Chen D, Wang H, Zhang Z, Ci L, Zhang X. Chemiluminescence determination of
cefotaxime sodium with flow-injection analysis of cerium (IV)-rhodamine 6G system
and its application to the binding study of cefotaxime sodium to protein with
on-line microdialysis sampling. Spectrochim Acta A Mol Biomol Spectrosc. 2011
Jan;78(1):553-7. doi: 10.1016/j.saa.2010.10.014. Epub 2010 Nov 3. PubMed PMID:
21050805.

8: Lalitha N, Pai PS. Development and validation of RP-HPLC method for estimation
of Cefotaxime sodium in marketed formulations. J Basic Clin Pharm. 2009
Dec;1(1):26-8. Epub 2010 Feb 15. PubMed PMID: 25206249; PubMed Central PMCID:
PMC4158899.

9: Zahid MA, Bakhsh R, Dar FS, Akhter N, Malik ZI. Comparison of single dose and
three dose antibiotic prophylaxis with cefotaxime sodium in cholecystectomy. J
Ayub Med Coll Abbottabad. 2003 Jan-Mar;15(1):38-40. PubMed PMID: 12870316.

10: Morelli B. Derivative spectrophotometry in the analysis of mixtures of
cefotaxime sodium and cefadroxil monohydrate. J Pharm Biomed Anal. 2003 Jun
1;32(2):257-67. PubMed PMID: 12763535.