Cefotiam hydrochloride

• CAT Number: I004495
• CAS Number: 66309-69-1
• Molecular Formula: C18H23N9O4S3•2HCl
• Molecular Weight: 598.56
• Purity: ≥95%
• Target: Antibiotic
• Solubility: DMSO: ≥ 6.1 mg/mL
• Storage: Store at -20℃
• IUPAC Name: (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrochloride
• InChI: InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
• InChIKey: BWRRTAXZCKVRON-DGPOFWGLSA-N
• SMILES: CN(C)CCN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O.Cl.Cl

Cefotiam Hydrochloride（Cat No.:I004495）is a third-generation cephalosporin antibiotic, used primarily to treat a wide range of bacterial infections, including respiratory, urinary tract, skin, and soft tissue infections. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. This broad-spectrum antibiotic is effective against both Gram-positive and Gram-negative bacteria. Cefotiam Hydrochloride is typically administered intravenously or intramuscularly in hospital settings. It is particularly valuable in treating infections in immunocompromised patients due to its potent antibacterial activity and favorable pharmacokinetic properties.

Reference

1:[Intraocular penetration of cefotiam hydrochloride, a kind of cephalosporin after filtration surgery in rabbit eyes]. Fukuda M, Takahashi N, Nakaizumi H, Yamashiro Y, Yamaguchi A.Nippon Ganka Gakkai Zasshi. 2005 Sep;109(9):559-62. Japanese. PMID: 16218433 2:Contact urticaria syndrome caused by patch testing with cefotiam hydrochloride. Chiba Y, Takahashi S, Yamakawa Y, Aihara M, Ikezawa Z.Contact Dermatitis. 1999 Oct;41(4):234. No abstract available. PMID: 10515116 3:[Cefotiam hydrochloride]. Shimizu K, Yamaguchi K.Jpn J Antibiot. 1994 Apr;47(4):349-56. Japanese. No abstract available. PMID: 8201765 4:Occupational contact urticaria syndrome from cefotiam hydrochloride. Miyahara H, Koga T, Imayama S, Hori Y.Contact Dermatitis. 1993 Oct;29(4):210-1. No abstract available. PMID: 8281787