Cefpodoxime Proxetil

For research use only. Not for therapeutic Use.

  • CAT Number: I012097
  • CAS Number: 87239-81-4
  • Molecular Formula: C21H27N5O9S2
  • Molecular Weight: 557.60
  • Purity: ≥95%
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Cefpodoxime proxetil (Cat No.:I012097) is an orally administered prodrug of cefpodoxime, a third-generation cephalosporin antibiotic. It exhibits a broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Cefpodoxime works by inhibiting bacterial cell wall synthesis through binding to specific penicillin-binding proteins (PBPs). This disrupts the integrity of the bacterial cell wall and leads to cell death. Cefpodoxime proxetil is commonly prescribed to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain sexually transmitted infections.


Catalog Number I012097
CAS Number 87239-81-4
Synonyms

(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 1-[[(1-Methylethoxy)carbonyl]oxy]ethyl Ester; Antibiotic CS 807; Banan; CS 807; Cefodox; Cefoprox; Ce

Molecular Formula C21H27N5O9S2
Purity ≥95%
Target Bacterial
Storage -80°C
IUPAC Name 1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChI InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1
InChIKey LTINZAODLRIQIX-FBXRGJNPSA-N
SMILES CC(C)OC(=O)OC(C)OC(=O)C1=C(CS[C@H]2N1C(=O)[C@H]2NC(=O)/C(=N\OC)/C3=CSC(=N3)N)COC
Reference

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1:Validated HPLC method for the pharmacokinetic study of oral extended-release cefpodoxime proxetil chitosan-alginate beads in rabbits. Mujtaba A, Kohli K.Int J Biol Macromol. 2017 May;98:111-116. doi: 10.1016/j.ijbiomac.2017.01.099. Epub 2017 Jan 27. PMID: 28137463<br />
2:In vitro/in vivo evaluation of HPMC/alginate based extended-release matrix tablets of cefpodoxime proxetil. Mujtaba A, Kohli K.Int J Biol Macromol. 2016 Aug;89:434-41. doi: 10.1016/j.ijbiomac.2016.05.010. Epub 2016 May 4. PMID: 27155235<br />
3:Characterization of impurities in cefpodoxime proxetil using LC-MS (n). Li J, Zhang D, Hu C.Acta Pharm Sin B. 2014 Aug;4(4):322-32. doi: 10.1016/j.apsb.2014.06.007. Epub 2014 Jul 14. PMID: 26579402 Free PMC Article<br />
4:Formulation of extended release cefpodoxime proxetil chitosan-alginate beads using quality by design approach. Mujtaba A, Ali M, Kohli K.Int J Biol Macromol. 2014 Aug;69:420-9. doi: 10.1016/j.ijbiomac.2014.05.066. Epub 2014 Jun 7. PMID: 24915550<br />
5:Natural gum as mucoadhesive controlled release carriers: evaluation of cefpodoxime proxetil by D-optimal design technique. Patil SH, Talele GS.Drug Deliv. 2014 Mar;21(2):118-29. doi: 10.3109/10717544.2013.834416. Epub 2013 Sep 13. PMID: 24032629<br />
6:Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium in Tablets. Acharya DR, Patel DB.Indian J Pharm Sci. 2013 Jan;75(1):31-5. doi: 10.4103/0250-474X.113538. PMID: 23901158 Free PMC Article<br />
7:Highly sensitive and selective high-performance liquid chromatography method for bioequivalence study of cefpodoxime proxetil in rabbit plasma via fluorescence labeling of its active metabolite. Ahmed S, Abdel-Wadood HM, Mohamed NA.J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:34-40. doi: 10.1016/j.jchromb.2013.06.036. Epub 2013 Jul 5. PMID: 23896427<br />
8:Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. Yilmaz H, Bilgi&ccedil; MA, Bavbek N, Ak&ccedil;ay A.Curr Drug Saf. 2013 Apr;8(2):145-7. PMID: 23845192<br />
9:Development and validation of spectrophotometric method of cefpodoxime proxetil using hydrotropic solubilizing agents. Asnani G, Jadhav K, Dhamecha D, Sankh A, Patil M.Pharm Methods. 2012 Jul;3(2):117-20. doi: 10.4103/2229-4708.103893. PMID: 23781491 Free PMC Article<br />
10:A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis. Kothadiya A.J Indian Med Assoc. 2012 Aug;110(8):580-3. PMID: 23741829

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