Cefpodoxime proxetil impurity B

• CAT Number: I014956
• CAS Number: 947692-14-0
• Molecular Formula: C₂₀H₂₅N₅O₈S₂
• Molecular Weight: 527.57
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C20H25N5O8S2/c1-8(2)31-20(29)33-10(4)32-18(28)14-9(3)6-34-17-13(16(27)25(14)17)23-15(26)12(24-30-5)11-7-35-19(21)22-11/h7-8,10,13,17H,6H2,1-5H3,(H2,21,22)(H,23,26)/b24-12-/t10?,13-,17-/m1/s1
• InChIKey: IETSABQUOKHCMQ-PUONPJMJSA-N
• SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)OC(C)OC(=O)OC(C)C

Cefpodoxime Proxetil Impurity B（Cat No.:I014956）is a specified impurity found in the synthesis or degradation of cefpodoxime proxetil, a third-generation cephalosporin antibiotic. This impurity is closely monitored and analyzed in pharmaceutical quality control to ensure the purity, efficacy, and safety of cefpodoxime products. Understanding and controlling Impurity B, along with other impurities, is critical in the manufacturing process to meet regulatory standards. Its study helps in refining production processes, enhancing drug stability, and maintaining therapeutic quality, ensuring that cefpodoxime proxetil remains effective for treating bacterial infections.

Reference

[1]. Iqbal S, et al. In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers. Pak J Pharm Sci. 2019 Mar;32(2 (Supplementary)):881-887.