For research use only. Not for therapeutic Use.
Cefpodoxime (Cefpodoxime acid) is a potent antibiotic active against gram-positive and gram-negative bacteria. Cefpodoxime inhibits the majority of cells in microbial populations. Cefpodoxime can be used for acute otitis media, sinusitis and tosillopharyngitis research[1][2].
Cefpodoxime (Cefpodoxime acid) inhibits gram-negative anaerobic rods (Bacteroidaceae) with MIC values of 0.125-4 mg/L. Cefpodoxime inhibits Veillonella parvula with MIC values of 0.25-8 mg/L. Cefpodoxime inhibits Peptostreptococcus micros, Peptostreptococcus asaccharolyticus and Ruminococcus bromii with MIC values of <2 mg/L[1].
Cefpodoxime (Cefpodoxime acid) inhibits bacterial populations of S. pneumoniae and S. pyogenes. cfu[2].
Cephalosporins (2.5-50 mg/kg; p.o.; every 8 hours; for 48 hours) have good curative effect in mice[3].
| Catalog Number | R004220 |
| CAS Number | 80210-62-4 |
| Synonyms | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Molecular Formula | C15H17N5O6S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 |
| InChIKey | WYUSVOMTXWRGEK-HBWVYFAYSA-N |
| SMILES | COCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O |
| Reference | [1]. Werner H, et, al. Comparative in vitro activity of cefpodoxime against anaerobes other than Bacteroides fragilis. Infection. 1991 Sep-Oct;19(5):377-9. [2]. Valentini S, et, al. In-vitro evaluation of cefpodoxime. J Antimicrob Chemother. 1994 Mar;33(3):495-508. [3]. Pérez-Trallero E, et, al. Prediction of in-vivo efficacy by in-vitro early bactericidal activity with oral beta-lactams, in a dose-ranging immunocompetent mouse sepsis model, using strains of Streptococcus pneumoniae with decreasing susceptibilities to penicillin. J Chemother. 2001 Apr;13(2):118-25. |
