For research use only. Not for therapeutic Use.
Cefradine（Cat No.:I003423）is a first-generation cephalosporin antibiotic effective against a range of Gram-positive and some Gram-negative bacteria. It works by disrupting bacterial cell wall synthesis, leading to cell lysis and death. Cefradine is commonly used to treat respiratory tract infections, skin infections, urinary tract infections, and otitis media. Known for its stability and good oral absorption, cefradine provides reliable efficacy in outpatient settings. Its broad-spectrum action and low resistance profile make Cefradine a valuable option for treating common bacterial infections in both clinical and home care environments.
| Catalog Number | I003423 |
| CAS Number | 38821-53-3 |
| Molecular Formula | C16H19N3O4S•H2O |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | DMSO: ≥ 3.6 mg/mL |
| Storage | 3 years -20℃ powder |
| IUPAC Name | (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChI | InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1 |
| InChIKey | RDLPVSKMFDYCOR-UEKVPHQBSA-N |
| SMILES | CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CCC=CC3)N)SC1)C(=O)O |
| Reference | </br>1:Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase. Fan X, Duan Q, Ke C, Zhang G, Xiao J, Wu D, Zeng X, Chen J, Guo J, Zhou J, Shi F, Zhu F.Oncotarget. 2016 Apr 26;7(17):24633-45. doi: 10.18632/oncotarget.8260. PMID: 27016423 Free PMC Article</br>2:Algal Feedback and Removal Efficiency in a Sequencing Batch Reactor Algae Process (SBAR) to Treat the Antibiotic Cefradine. Chen J, Zheng F, Guo R.PLoS One. 2015 Jul 15;10(7):e0133273. doi: 10.1371/journal.pone.0133273. eCollection 2015. PMID: 26177093 Free PMC Article</br>3:Antioxidative responses of Pseudomonas fluorescens YZ2 to simultaneous exposure of Zn and Cefradine. Xu YB, Xu JX, Chen JL, Huang L, Zhou SQ, Zhou Y, Wen LH.Ecotoxicology. 2015 Oct;24(7-8):1788-97. doi: 10.1007/s10646-015-1516-7. Epub 2015 Jul 4. PMID: 26141733 </br>4:Endogenous nitric oxide in Pseudomonas fluorescens ZY2 as mediator against the combined exposure to zinc and cefradine. Xu YB, Zhou Y, Ruan JJ, Xu SH, Gu JD, Huang SS, Zheng L, Yuan BH, Wen LH.Ecotoxicology. 2015 May;24(4):835-43. doi: 10.1007/s10646-015-1428-6. Epub 2015 Feb 13. PMID: 25678231 </br>5:LC/UV determination of cefradine, cefuroxime, and cefotaxime in dairy milk, human serum and wastewater samples. Qureshi T, Memon N, Memon SQ, Abro K, Shah SW.Springerplus. 2013 Oct 29;2:575. doi: 10.1186/2193-1801-2-575. eCollection 2013. PMID: 24255868 Free PMC Article</br>6:Structures of cefradine dihydrate and cefaclor dihydrate from DFT-D calculations. van de Streek J, Rantanen J, Bond AD.Acta Crystallogr C. 2013 Nov;69(Pt 11):1229-33. doi: 10.1107/S0108270113026863. Epub 2013 Oct 19. PMID: 24192164 </br>7:Access the toxic effect of the antibiotic cefradine and its UV light degradation products on two freshwater algae. Chen JQ, Guo RX.J Hazard Mater. 2012 Mar 30;209-210:520-3. doi: 10.1016/j.jhazmat.2012.01.041. Epub 2012 Jan 20. PMID: 22305202 </br>8:Isolation and structural elucidation of an impurity of cefradine. Zhu Y, Hendrix C, Busson R, Janssen G, Roets E, Hoogmartens J.J Pharm Biomed Anal. 1994 Sep;12(9):1137-40. PMID: 7803564 </br>9:A comparative study of LC methods for analysis of cefradine. Hendrix C, Yongxin Z, Pijcke M, Roets E, Hoogmartens J.J Pharm Biomed Anal. 1993 Jul;11(7):595-9. PMID: 8399534 </br>10:[Study on the effect of cefradine (sefril) on results of determining concentration of uric acid in serum]. Grochowina T, Strzykała K, Makowska M, Guziołek E.Wiad Lek. 1993 May;46(9-10):360-3. Polish. PMID: 8236993 |
