Ceftibuten dihydrate

• CAT Number: I000642
• CAS Number: 118081-34-8
• Molecular Formula: C15H18N4O8S2
• Molecular Weight: 446.46
• Purity: ≥95%
• Target: C1C=C(N2C(S1)C(C2=O)NC(=O)C(=CCC(=O)O)C3=CSC(=N3)N)C(=O)O.O.O
• Solubility: DMSO:35mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: (6R,7R)-7-[[(Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrate
• InChI: InChI=1S/C15H14N4O6S2.2H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);2*1H2/b6-1-;;/t10-,13-;;/m1../s1
• InChIKey: SSWTVBYDDFPFAF-DKOGRLLHSA-N
• SMILES: C1C=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)/C(=C\CC(=O)O)/C3=CSC(=N3)N)C(=O)O.O.O

Ceftibuten Dihydrate（Cat No.:I000642）is a third-generation cephalosporin antibiotic effective against various Gram-negative and some Gram-positive bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Ceftibuten is commonly used to treat respiratory tract infections, such as bronchitis and otitis media, as well as urinary tract infections. Its dihydrate form enhances stability and solubility, making it suitable for oral administration. Known for its high bioavailability and once-daily dosing, Ceftibuten offers a convenient option for treating infections in outpatient settings.

 

Reference

1: Hayashi I, Onuma K, Hasuike M, Ishii T. [Clinical examination of ceftibuten in
acute bronchitis]. Jpn J Antibiot. 1990 May;43(5):761-7. Japanese. PubMed PMID:
2391747.

2: Hashimoto H, Yamaguchi S, Yachiku S. [Clinical studies of ceftibuten in the
field of urology]. Jpn J Antibiot. 1990 Feb;43(2):355-61. Japanese. PubMed PMID:
2362357.

3: Jones RN, Barry AL. Ceftibuten (7432-S, SCH 39720): comparative antimicrobial
activity against 4735 clinical isolates, beta-lactamase stability and broth
microdilution quality control guidelines. Eur J Clin Microbiol Infect Dis. 1988
Dec;7(6):802-7. PubMed PMID: 3145869.

4: Jones RN, Barry AL. In vitro evaluation of ceftibuten (7432-S, SCH 39720), a
novel orally administered cephalosporin. Chemioterapia. 1988 Oct;7(5):283-6.
PubMed PMID: 3147148.