Ceftolozane

• CAT Number: I005927
• CAS Number: 689293-68-3
• Molecular Formula: C23H30N12O8S2
• Molecular Weight: 666.69
• Purity: ≥95%
• Synonyms: CXA-101; CXA101; CXA 101; FR264205; FR 264205; FR-264205; Ceftolozane brand name: Zerbaxa (with tazobactam).;(6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-meth
• Target: beta-lactam antibiotic
• Solubility: Soluble in DMSO.
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: (6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C23H30N12O8S2/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42)/b31-11-/t12-,18-/m1/s1
• InChIKey: JHFNIHVVXRKLEF-DCZLAGFPSA-N
• SMILES: CC(C)(C(=O)O)ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)[O-]

Ceftolozane(CAT: I005927) is a fifth-generation cephalosporin antibiotic known for its strong activity against Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is often combined with the β-lactamase inhibitor tazobactam to overcome bacterial resistance. Ceftolozane works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. This antibiotic is crucial in research focused on combating multidrug-resistant bacterial infections, especially in hospital-acquired infections like complicated urinary tract infections (cUTIs) and complicated intra-abdominal infections (cIAIs). Its efficacy against resistant pathogens makes it a vital tool for studies on antibiotic resistance and new therapeutic strategies.