For research use only. Not for therapeutic Use.
Ceftolozane sulfate（Cat No.:I005928）, is a synthetic antibiotic used to combat bacterial infections. It belongs to the cephalosporin class and is often combined with tazobactam to create an effective combination against certain multi-drug resistant Gram-negative bacteria. Ceftolozane sulfate works by inhibiting bacterial cell wall synthesis. It’s used to treat complicated urinary tract infections, intra-abdominal infections, and hospital-acquired pneumonia. Its specificity for Gram-negative pathogens and effectiveness against resistant strains make it valuable in addressing challenging infections.
| Catalog Number | I005928 |
| CAS Number | 936111-69-2 |
| Synonyms | FR-264205; FR264205; FR 264205;mono(5-amino-2-(((6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyr |
| Molecular Formula | C23H32N12O12S3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | -20 °C |
| IUPAC Name | (6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrogen sulfate |
| InChI | InChI=1S/C23H30N12O8S2.H2O4S/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24;1-5(2,3)4/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42);(H2,1,2,3,4)/b31-11-;/t12-,18-;/m1./s1 |
| InChIKey | UJDQGRLTPBVSFN-TVNHLQOTSA-N |
| SMILES | CC(C)(C(=O)O)ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O.OS(=O)(=O)[O-] |
| Reference | 1:Aust Prescr. 2016 Jun;39(3):106-7. doi: 10.18773/austprescr.2016.044. Epub 2016 Apr 18. Ceftolozane sulfate with tazobactam sodium. PMID: 27346919 PMCID: PMC4919178 DOI: 10.18773/austprescr.2016.044<br /> |
