Ceftriaxone

• CAT Number: I004731
• CAS Number: 73384-59-5
• Molecular Formula: C18H18N8O7S3
• Molecular Weight: 554.58
• Purity: ≥95%
• Target: Antibacterial
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• InChI: InChI1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1
• InChIKey: VAAUVRVFOQPIGI-SPQHTLEESA-N
• SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=NOC)/C4=CSC(=N4)N)SC2)C(=O)O

Ceftriaxone（Cat No.:I004731）is a broad-spectrum, third-generation cephalosporin antibiotic widely used to treat serious bacterial infections, including respiratory, urinary, and bloodstream infections, as well as meningitis. It works by inhibiting bacterial cell wall synthesis, effectively targeting both gram-positive and gram-negative organisms. Known for its long half-life, Ceftriaxone is typically administered via injection or intravenous infusion, allowing for once-daily dosing, which improves patient compliance. It’s often a first-line treatment in hospitals due to its potency, low resistance rate, and effectiveness in managing severe infections in both adults and children.

Reference

[1]. Lee, S.G., et al., Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem, 2008. 283(19): p. 13116-23.