Ceftriaxone sodium salt

• CAT Number: I004767
• CAS Number: 74578-69-1
• Molecular Formula: C₁₈H₁₇N₈NaO₇S₃
• Molecular Weight: 576.60
• Purity: ≥95%
• Target: Antibacterial
• Solubility: H2O: ＞ 40 mg/mL
• Storage: Store at -20C
• IUPAC Name: sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C18H18N8O7S3.Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);/q;+1/p-1/b24-8-;/t9-,15-;/m1./s1
• InChIKey: YOBPSXOHCHDCMU-VKZZUTNHSA-M
• SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

Ceftriaxone sodium salt（Cat No.:I004767）is a third-generation cephalosporin antibiotic used extensively in the treatment of bacterial infections, particularly those resistant to first-line treatments. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Effective against a broad spectrum of gram-positive and gram-negative bacteria, ceftriaxone is commonly used for respiratory, urinary, skin, and bloodstream infections, as well as meningitis. Its long half-life allows for once-daily dosing, making it convenient for hospital and outpatient use. Ceftriaxone sodium salt is crucial in managing severe and resistant infections.

Reference

[1]. Lee, S.G., et al., Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem, 2008. 283(19): p. 13116-23.