Cefuroxime sodium

For research use only. Not for therapeutic Use.

  • CAT Number: A000080
  • CAS Number: 56238-63-2
  • Molecular Formula: C16H15N4NaO8S
  • Molecular Weight: 446.37
  • Purity: ≥95%
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Cefuroxime Sodium(Cat No.:A000080)is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections, including respiratory tract, skin, and urinary infections. It works by inhibiting bacterial cell wall synthesis, which leads to cell death, and is effective against both Gram-positive and Gram-negative bacteria. The sodium salt form enhances its solubility for intravenous or intramuscular administration, allowing rapid action in severe infections. Cefuroxime Sodium is commonly employed in clinical settings for conditions like pneumonia, meningitis, and sepsis, valued for its stability against certain β-lactamase enzymes.


Catalog Number A000080
CAS Number 56238-63-2
Synonyms

Cefuroxime sodium;

Molecular Formula C16H15N4NaO8S
Purity ≥95%
Target Beta-lactamase
Storage Store at -20°C
IUPAC Name sodium;(6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChI InChI=1S/C16H16N4O8S.Na/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20;/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24);/q;+1/p-1/b19-9-;/t10-,14-;/m1./s1
InChIKey URDOHUPGIOGTKV-JTBFTWTJSA-M
SMILES CO/N=C(/C1=CC=CO1)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)[O-].[Na+]
Reference

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1:[Influence of cefuroxime sodium on synaptic plasticity of parallel fiber-Purkinje cells in young rats]. He HY, Ren YG, Li L, Jin FL, DU YP, Zhang YP.Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jun;18(6):558-63. Chinese. PMID: 27324547 Free Article<br />
2:Development and validation of a rapid turbidimetric assay to determine the potency of cefuroxime sodium in powder for dissolution for injection. Vieira DC, Fiuza TF, Salgado HR.Pathogens. 2014 Jul 30;3(3):656-66. doi: 10.3390/pathogens3030656. PMID: 25438016 Free PMC Article<br />
3:Optimization and validation of spectrofluorimetric method for determination of cefadroxile and cefuroxime sodium in pharmaceutical formulations. Elbashir AA, Ahmed SM, Aboul-Enein HY.Luminescence. 2013 Jul-Aug;28(4):490-5. doi: 10.1002/bio.2481. Epub 2013 Jan 24. PMID: 23345111 <br />
4:Bioequivalence and population pharmacokinetic modeling of two forms of antibiotic, cefuroxime lysine and cefuroxime sodium, after intravenous infusion in beagle dogs. Zhao L, Li Q, Li X, Yin R, Chen X, Geng L, Bi K.J Biomed Biotechnol. 2012;2012:507294. doi: 10.1155/2012/507294. Epub 2012 Jul 15. PMID: 22911056 Free PMC Article<br />
5:Comparison of HPLC and UV spectrophotometric methods for the determination of cefuroxime sodium in pharmaceutical products. Vieira DC, Salgado HR.J Chromatogr Sci. 2011 Aug;49(7):508-11. PMID: 21801481 <br />
6:Role of liquid membrane phenomenon in the anti-bacterial activity of Cefuroxime Sodium. Nagesh C, Shankaraiah MM, Venkatesh JS, Setty SR.J Basic Clin Pharm. 2010 Mar;1(2):77-80. Epub 2010 May 15. PMID: 24825969 Free PMC Article<br />
7:Development and validation of a microbiological agar assay for determination of cefuroxime sodium in pharmaceutical preparations. Schmidt CA, Agarrayua DA, Laporta LV, Machado JC, Manfio ML, Bittencourt CF.J Microbiol Methods. 2009 Jun;77(3):308-15. doi: 10.1016/j.mimet.2009.03.012. Epub 2009 Apr 1. PMID: 19344741 <br />
8:Chemical stability of cefuroxime sodium after reconstitution in 0.9% sodium chloride injection and storage in polypropylene syringes for pediatric use. Gupta VD.Int J Pharm Compd. 2003 Jul-Aug;7(4):310-2. PMID: 23979702 <br />
9:Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats. ABO EL-SOOUD K, El-Banna HA, Hanafy MS, Goudah A.Res Vet Sci. 2000 Dec;69(3):219-24. PMID: 11124092 <br />
10:Stability of cefuroxime sodium and aminophylline or theophylline. Stewart JT, Warren FW, Johnson SM.Am J Hosp Pharm. 1994 Mar 15;51(6):809-11. No abstract available. PMID: 8010322

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