Cemtirestat

• CAT Number: I024362
• CAS Number: 309283-89-4
• Molecular Formula: C11H8N4O2S
• Molecular Weight: 260.271
• Purity: 98%
• Synonyms: Cemtirestat
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,3-Dihydro-3-thioxo-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid
• InChI: InChI=1S/C11H8N4O2S/c16-8(17)5-15-7-4-2-1-3-6(7)9-10(15)12-11(18)14-13-9/h1-4H,5H2,(H,16,17)(H,12,14,18)
• InChIKey: LCMDWJXBUZDEKA-UHFFFAOYSA-N
• SMILES: O=C(O)CN1C(C(C2=C1C=CC=C2)=NN3)=NC3=S

Cemtirestat is an aldose reductase inhibitor

Reference

1: Hlavac M, Kovacikova L, Soltesova Prnova M, Šramel P, Addova G, Majekova M,
Hanquet G, Bohac A, Stefek M. Development of novel oxotriazinoindole inhibitors
of aldose reductase: isosteric sulfur/oxygen replacement in the
thioxotriazinoindole cemtirestat markedly improved inhibition selectivity. J Med
Chem. 2019 Dec 10. doi: 10.1021/acs.jmedchem.9b01747. [Epub ahead of print]
PubMed PMID: 31820975.
2: Prnova MS, Kovacikova L, Svik K, Bezek S, Elmazoğlu Z, Karasu C, Stefek M.
Triglyceride-lowering effect of the aldose reductase inhibitor
cemtirestat-another factor that may contribute to attenuation of symptoms of
peripheral neuropathy in STZ-diabetic rats. Naunyn Schmiedebergs Arch Pharmacol.
2019 Dec 5. doi: 10.1007/s00210-019-01769-1. [Epub ahead of print] PubMed PMID:
31802170.
3: Soltesova Prnova M, Svik K, Bezek S, Kovacikova L, Karasu C, Stefek M.
3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates
Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A
Role of Aldose Reductase. Neurochem Res. 2019 May;44(5):1056-1064. doi:
10.1007/s11064-019-02736-1. Epub 2019 Jan 28. PubMed PMID: 30689163.