Cemtirestat

• CAT Number: I024362
• CAS Number: 309283-89-4
• Molecular Formula: C11H8N4O2S
• Molecular Weight: 260.27
• Purity: 98%
• Synonyms: Cemtirestat
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(3-sulfanylidene-2H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
• InChI: InChI=1S/C11H8N4O2S/c16-8(17)5-15-7-4-2-1-3-6(7)9-10(15)12-11(18)14-13-9/h1-4H,5H2,(H,16,17)(H,12,14,18)
• InChIKey: LCMDWJXBUZDEKA-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C3=NNC(=S)N=C3N2CC(=O)O

Cemtirestat（Cat No.:I024362）is an investigational drug being studied for its potential in treating hereditary optic neuropathies, such as Leber’s hereditary optic neuropathy (LHON). It works as an oral antioxidant and mitochondrial targeting agent, aimed at protecting retinal ganglion cells from damage caused by mitochondrial dysfunction and oxidative stress, which are central to these conditions. By improving mitochondrial function, cemtirestat has shown promise in preclinical studies and early clinical trials in preserving vision and slowing down disease progression. Further research is needed to establish its long-term safety, efficacy, and therapeutic potential in optic nerve diseases.