For research use only. Not for therapeutic Use.
Cenicriviroc(Cat No.:I005930)is a dual antagonist of the chemokine receptors CCR2 and CCR5, developed for the treatment of non-alcoholic steatohepatitis (NASH) and HIV. By blocking CCR2, it reduces inflammation by inhibiting the recruitment of inflammatory monocytes, while CCR5 inhibition helps prevent the entry of HIV into host cells. Cenicriviroc has been studied for its anti-inflammatory and anti-fibrotic effects, particularly in liver disease, where it may reduce the progression of fibrosis. Its dual-action mechanism makes it a promising candidate for managing inflammatory and fibrotic conditions.
CAS Number | 497223-25-3 |
Synonyms | TAK-652; TAK652; TAK 652; TBR-652; TBR 652; TBR652; Cenicriviroc.;(S,E)-8-(4-(2-Butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide |
Molecular Formula | C41H52N4O4S |
Purity | ≥95% |
Target | Immunology/Inflammation |
Solubility | Soluble in DMSO, not in water |
Storage | 0 - 4°C for short term ,or -20 °C for long term |
Overview of Clinical Research | Originator: National Institute for Health Research; Takeda<br /> |
IUPAC Name | (5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-[4-[(S)-(3-propylimidazol-4-yl)methylsulfinyl]phenyl]-3,4-dihydro-2H-1-benzazocine-5-carboxamide |
InChI | InChI=1S/C41H52N4O4S/c1-5-7-22-48-23-24-49-38-15-10-32(11-16-38)33-12-19-40-35(25-33)26-34(9-8-21-44(40)28-31(3)4)41(46)43-36-13-17-39(18-14-36)50(47)29-37-27-42-30-45(37)20-6-2/h10-19,25-27,30-31H,5-9,20-24,28-29H2,1-4H3,(H,43,46)/b34-26+/t50-/m0/s1 |
InChIKey | PNDKCRDVVKJPKG-WHERJAGFSA-N |
SMILES | CCCCOCCOC1=CC=C(C=C1)C2=CC/3=C(C=C2)N(CCC/C(=C3)/C(=O)NC4=CC=C(C=C4)[S@@](=O)CC5=CN=CN5CCC)CC(C)C |
Reference | 1. Antimicrob Agents Chemother. 2007 Feb;51(2):707-15. Epub 2006 Nov 20. <br /> |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |