For research use only. Not for therapeutic Use.
Censavudine（Cat No.:I005933） is a promising nucleoside reverse transcriptase inhibitor (NRTI) under investigation for its potential in treating HIV infections. It works by targeting the reverse transcriptase enzyme, inhibiting viral replication and reducing the viral load in infected cells. With a unique resistance profile and improved pharmacokinetics, Censavudine offers potential advantages over existing NRTIs. Its application in research focuses on understanding viral dynamics, drug resistance mechanisms, and the optimization of antiretroviral therapies. Censavudine represents a valuable tool in advancing HIV treatment strategies and improving patient outcomes.
| Catalog Number | I005933 |
| CAS Number | 634907-30-5 |
| Synonyms | OBP-601; OBP601; OBP 601; BMS-986001; BMS 986001; BMS986001; festinavir; 4′-Ed4T; Censavudine.;1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione |
| Molecular Formula | C12H12N2O4 |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methylpyrimidine-2,4-dione |
| InChI | InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1 |
| InChIKey | OSYWBJSVKUFFSU-SKDRFNHKSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@](O2)(CO)C#C |
| Reference | </br> 1: Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, Osiyemi O, Santoscoy M, Ray N, Stock DA, Joshi SR, Hanna GJ, Lataillade M. Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial. Lancet HIV. 2016 Jan;3(1):e13-22. doi: 10.1016/S2352-3018(15)00231-3. Epub 2015 Dec 12. PubMed PMID: 26762988. |
