For research use only. Not for therapeutic Use.
Centanafadine, also known as EB-1020, is an adrenergic uptake inhibitor and dopamine uptake inhibitor and serotonin uptake inhibitor. Centanafadine modulates norepinephrine, dopamine and, to a lesser extent, serotonin reuptake in a ratio of 1:6:14, respectively to improve focus, attention and executive function.
| Catalog Number | I005934 |
| CAS Number | 923981-14-0 (HCl salt) |
| Synonyms | EB-1020; EB 1020; EB1020; EB-1020 SR; CTN SR; Centanafadine;(1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochoride |
| Molecular Formula | C15H16ClN |
| Purity | ≥95% |
| Target | adrenergic uptake inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| InChI | InChI=1S/C15H15N.ClH/c1-2-4-12-7-13(6-5-11(12)3-1)15-8-14(15)9-16-10-15;/h1-7,14,16H,8-10H2;1H/t14-,15+;/m1./s1 |
| InChIKey | ACVMJAJGCQUPKX-LIOBNPLQSA-N |
| SMILES | [H][C@@]12CNC[C@]1(C3=CC=C4C=CC=CC4=C3)C2.[H]Cl |
| Reference | </br>1:Effects of Clove Oil and Lidocaine-HCl Anesthesia on Water Parameter during Simulated Transportation in the Marine Medaka, <i>Oryzias dancena</i>. Park IS, Gil HW, Lee TH, Nam YK, Lim SG, Kim DS.Dev Reprod. 2017 Mar;21(1):19-33. doi: 10.12717/DR.2017.21.1.019. Epub 2017 Mar 31. PMID: 28484741 Free PMC Article</br>2:Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Al-Quraishy S, Othman MS, Dkhil MA, Abdel Moneim AE.Biomed Pharmacother. 2017 Apr 29;91:338-349. doi: 10.1016/j.biopha.2017.04.069. [Epub ahead of print] PMID: 28463797 </br>3:HCl dissociating on a rigid Au(111) surface: A six-dimensional quantum mechanical study on a new potential energy surface based on the RPBE functional. Liu T, Fu B, Zhang DH.J Chem Phys. 2017 Apr 28;146(16):164706. doi: 10.1063/1.4982051. PMID: 28456190 </br>4:A new ab initio potential energy surface of LiClH (1A/’) system and quantum dynamics calculation for Li + HCl (v = 0, j = 0-2) → LiCl + H reaction. Tan RS, Zhai HC, Yan W, Gao F, Lin SY.J Chem Phys. 2017 Apr 28;146(16):164305. doi: 10.1063/1.4982066. PMID: 28456188 </br>5:Spectroscopic Characterization of the Reaction Products between the Criegee Intermediate CH<sub>2</sub> OO and HCl. Cabezas C, Endo Y.Chemphyschem. 2017 Apr 27. doi: 10.1002/cphc.201700446. [Epub ahead of print] PMID: 28449411 </br>6:Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA.Drug Des Devel Ther. 2017 Apr 3;11:1081-1093. doi: 10.2147/DDDT.S131936. eCollection 2017. PMID: 28435220 Free PMC Article</br>7:Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Qazi F, Shoaib MH, Yousuf RI, Nasiri MI, Ahmed K, Ahmad M.Lipids Health Dis. 2017 Apr 12;16(1):75. doi: 10.1186/s12944-017-0466-x. PMID: 28403892 Free PMC Article</br>8:Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cadaret CN, Beede KA, Riley HE, Yates DT.Cytokine. 2017 Apr 5;96:107-113. doi: 10.1016/j.cyto.2017.03.014. [Epub ahead of print] PMID: 28390265 </br>9:Effects of anabolic implants and ractopamine-HCl on muscle fiber morphometrics, collagen solubility, and tenderness of beef longissimus lumborum steaks. Ebarb SM, Phelps KJ, Drouillard JS, Maddock-Carlin KR, Vaughn MA, Burnett DD, Noel JA, Van Bibber-Krueger CL, Paulk CB, Grieger DM, Gonzalez JM.J Anim Sci. 2017 Mar;95(3):1219-1231. doi: 10.2527/jas.2016.1263. PMID: 28380530 </br>10:Comparative plasma and tissue distribution of Sun Pharma/’s generic doxorubicin HCl liposome injection versus Caelyx<sup>®</sup> (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague-Dawley rats. Burade V, Bhowmick S, Maiti K, Zalawadia R, Jain D, Rajamannar T.Cancer Chemother Pharmacol. 2017 May;79(5):899-913. doi: 10.1007/s00280-017-3278-9. Epub 2017 Mar 27. PMID: 28349166 Free PMC Article |
