Cephalexin monohydrate

• CAT Number: I002777
• CAS Number: 23325-78-2
• Molecular Formula: C16H19N3O5S
• Molecular Weight: 365.40
• Purity: ≥95%
• Synonyms: (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate
• Target: Penicillin-binding protein (PBP)
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• InChI: InChI=1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15-;/m1./s1
• InChIKey: AVGYWQBCYZHHPN-CYJZLJNKSA-N
• SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)SC1)C(=O)O.O

Cephalexin monohydrate (Cat No.:I002777) is a cephalosporin antibiotic used for the treatment of various bacterial infections. It belongs to the first-generation cephalosporin class and exerts its pharmacologic action by inhibiting bacterial cell wall synthesis. Cephalexin binds to penicillin-binding proteins (PBPs), which are essential for the formation of the bacterial cell wall. This disruption leads to cell lysis and ultimately eradicates susceptible bacteria. Cephalexin is commonly prescribed for the treatment of skin and soft tissue infections, respiratory tract infections, urinary tract infections, and certain types of otitis media. It is widely used due to its effectiveness, safety profile, and broad spectrum of activity against both Gram-positive and some Gram-negative bacteria.

Reference

1. Speight TM, et al. Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties. Drugs. 1972;3(1):9-78.
2. Tanrisever B, et al. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Drugs. 1986;32 Suppl 3:1-16.