Cephaloridine hydrate

• CAT Number: I041659
• CAS Number: 102039-86-1
• Molecular Formula: C19H19N3O5S2
• Molecular Weight: 433.50
• Purity: ≥95%
• Synonyms: (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrate
• InChI: InChI=1S/C19H17N3O4S2.H2O/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21;/h1-8,15,18H,9-11H2,(H-,20,23,25,26);1H2/t15-,18-;/m1./s1
• InChIKey: KZYZSCXFERELNV-KQKCUOLZSA-N
• SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4.O

Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity[1][2].
Cephaloridine hydrate can inhibit Staphylococcus aureus penicillin-sensitive strains, penicillin-resistant strains, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae, Clostridium septicum, and so on, with MICs of 0.05-1 μg/mL[1].
Cephaloridine hydrate (50-500 mg/kg; i.m.) exhibits dose-related nephrotoxicity in rabbits and monkeys[2].

Reference

[1]. P. W. Muggleton, et al. Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin). Br Med J. 1964 Nov 14;2(5419):1234-7.
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[2]. Perkins RL, et al. Cephaloridine and cephalothin: comparative studies of potential nephrotoxicity. J Lab Clin Med. 1968 Jan;71(1):75-84.
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