Cephalotaxlen

• CAT Number: I002813
• CAS Number: 24316-19-6
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.36
• Purity: ≥95%
• Target: Flavivirus
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol
• InChI: InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
• InChIKey: YMNCVRSYJBNGLD-KURKYZTESA-N
• SMILES: COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5

Cephalotaxine（Cat No.:I002813）is a natural alkaloid derived from the Cephalotaxus plant genus, known for its potent anticancer properties. It serves as the base compound for homoharringtonine (HHT), a chemotherapeutic agent used in leukemia treatment. Cephalotaxine works by inhibiting protein synthesis in cancer cells, hindering their growth and proliferation. Due to its bioactive profile, cephalotaxine is valuable in cancer research, particularly in studying cell cycle arrest and apoptosis mechanisms. Its natural origin and therapeutic potential make it an important compound in pharmacology and oncology studies.

Reference

[1]. Wang DZ, et al. Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity Yao Xue Xue Bao. 1992;27(3):178-84.

[2]. Efferth T, et al. Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):56-67.