Cephalothin

• CAT Number: A000085
• CAS Number: 58-71-9
• Molecular Formula: C16H15N2NaO6S2
• Molecular Weight: 418.42
• Purity: ≥95%
• Synonyms: Cefalotin
• Storage: -20°C
• IUPAC Name: sodium;(6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
• InChIKey: VUFGUVLLDPOSBC-XRZFDKQNSA-M
• SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)[O-].[Na+]

Cephalothin（Cat No.:A000085）is a first-generation cephalosporin antibiotic effective against a broad range of Gram-positive bacteria and some Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Commonly used to treat infections such as respiratory tract infections, skin infections, and urinary tract infections, cephalothin is often administered intravenously due to its low oral bioavailability. Known for its stability against certain beta-lactamases, it remains a reliable choice in clinical settings, particularly for patients requiring alternatives to penicillin-based antibiotics.

Reference

Georgopapadakou, N. H. /Mechanisms of Action of Cephalosporin 3/’-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli./ American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.