Cercosporamide

• CAT Number: I001208
• CAS Number: 131436-22-1
• Molecular Formula: C₁₆H₁₃NO₇
• Molecular Weight: 331.28
• Purity: 95%
• Synonyms: (9aS)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamide
• Target: JAK
• Solubility: 10 mM in DMSO
• Appearance: Light to dark tan solid
• Storage: Store at -20°C
• Analysis method: HPLC
• InChI: InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/m1/s1
• InChIKey: GEWLYFZWVLXQME-MRXNPFEDSA-N
• SMILES: CC(=O)C1=C(C=C2[C@@](C1=O)(C3=C(C=C(C(=C3O2)C(=O)N)O)O)C)O

Cercosporamide (Cat No.:I001208) was initially discovered as a host-selective phytotoxin and a broad-spectrum antifungal compound derived from Cercosporidium henningsii. However, further research has revealed its inhibitory activity on a cell wall integrity pathway mediated by a serine/threonine protein kinase called Pkc1. This pathway plays a crucial role in cell wall biosynthesis. Cercosporamide acts as a potent and selective inhibitor of Pkc1 kinase, with an IC50 value of less than 50 nM. By targeting Pkc1, cercosporamide disrupts the cell wall integrity pathway, potentially leading to the inhibition of fungal growth and the identification of novel antifungal strategies.

Reference

[1]. Altman JK, et al. Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121(18):3675-3681.