For research use only. Not for therapeutic Use.
Cetaben is a unique, peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.
| Catalog Number | I005964 |
| CAS Number | 55986-43-1 |
| Synonyms | Cetaben;4-(hexadecylamino)-benzoic acid |
| Molecular Formula | C23H39NO2 |
| Purity | ≥95% |
| Target | PPAR |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-(hexadecylamino)benzoic acid |
| InChI | InChI=1S/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)23(25)26/h16-19,24H,2-15,20H2,1H3,(H,25,26) |
| InChIKey | QXWKHSSBFQDQPR-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCNC1=CC=C(C=C1)C(=O)O |
| Reference | </br>1:The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Kovacs WJ, Schrader M, Walter I, Stangl H.Histochem Cell Biol. 2004 Aug;122(2):95-109. Epub 2004 Jul 28. PMID: 15322860 </br>2:Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma cells and HepG2 human hepatoblastoma cells. Kovacs W, Walter I, Stangl H.Histochem Cell Biol. 2001 Jun;115(6):509-19. PMID: 11455451 </br>3:Cetaben is an exceptional type of peroxisome proliferator. Chandoga J, Hampl L, Turecký L, Rojeková I, Uhliková E, Hocman G.Int J Biochem. 1994 May;26(5):679-96. PMID: 8005353 </br>4:Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Chandoga J, Rojeková I, Hampl L, Hocman G.Biochem Pharmacol. 1994 Feb 9;47(3):515-9. PMID: 8117320 </br>5:Effects of hypolipidaemics cetaben and clofibrate on mitochondrial and peroxisomal enzymes of rat liver. Schön HJ, Grgurin M, Klune G, Prager C, Marz R, Legenstein E, Böck P, Kramar R.J Pharm Pharmacol. 1994 Feb;46(2):144-7. PMID: 8021805 </br>6:Cetaben versus clofibrate: comparison of toxicity and peroxisome proliferation in rats. Fort FL, Stein HH, Langenberg K, Lewkowski JP, Heyman IA, Kesterson JW.Toxicology. 1983 Nov;28(4):305-11. PMID: 6606240 </br>7:Potential antiatherosclerotic agents. 4. [(Functionalized-alkyl)amino]benzoic acid analogues of cetaben. DeVries VG, Largis EE, Miner TG, Shepherd RG, Upeslacis J.J Med Chem. 1983 Oct;26(10):1411-21. PMID: 6604818 </br>8:Potential antiatherosclerotic agents. 3. Substituted benzoic and non benzoic acid analogues of cetaben. Albright JD, DeVries VG, Du MT, Largis EE, Miner TG, Reich MF, Shepherd RG.J Med Chem. 1983 Oct;26(10):1393-411. PMID: 6604817 </br>9:Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino) benzoic acid analogues of cetaben. Albright JD, DeVries VG, Largis EE, Miner TG, Reich MF, Schaffer SA, Shepherd RG, Upeslacis J.J Med Chem. 1983 Oct;26(10):1378-93. PMID: 6604816 </br>10:Antiatherogenic activity of cetaben sodium, sodium p-(hexadecylamino) benzoate, in the aortae of hypercholesteremic rabbits subjected to aortic endothelial cell desquamation. Katocs AS Jr, Schaffer SA.Artery. 1982;11(3):192-206. PMID: 6985202 |
