For research use only. Not for therapeutic Use.
Cetilistat (Cat No.: I002957) is a promising medication designed to combat obesity in both diabetic and non-diabetic patients. This novel compound functions as a potent pancreatic lipase inhibitor, primarily targeting gastrointestinal and pancreatic lipases. By inhibiting these enzymes, Cetilistat reduces the breakdown and absorption of dietary fats in the gastrointestinal tract. It is highly lipophilic, facilitating its therapeutic action. Cetilistat has shown safety and tolerability in vivo, making it an appealing option for individuals struggling with obesity.
| Catalog Number | I002957 |
| CAS Number | 282526-98-1 |
| Molecular Formula | C25H39NO3 |
| Purity | ≥95% |
| Target | pancreatic lipase inhibitor |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 2-hexadecoxy-6-methyl-3,1-benzoxazin-4-one |
| InChI | InChI=1S/C25H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25/h17-18,20H,3-16,19H2,1-2H3 |
| InChIKey | MVCQKIKWYUURMU-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C=C2)C)C(=O)O1 |
| Reference | </br>1:Cetilistat for the treatment of obesity. Gras J.Drugs Today (Barc). 2013 Dec;49(12):755-9. doi: 10.1358/dot.2013.49.12.2099318. PMID: 24524093 </br>2:Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical). Kopelman P, Groot Gde H, Rissanen A, Rossner S, Toubro S, Palmer R, Hallam R, Bryson A, Hickling RI.Obesity (Silver Spring). 2010 Jan;18(1):108-15. doi: 10.1038/oby.2009.155. Epub 2009 May 21. PMID: 19461584 Free Article</br>3:Reduction of dietary fat absorption by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers. Bryson A, de la Motte S, Dunk C.Br J Clin Pharmacol. 2009 Mar;67(3):309-15. doi: 10.1111/j.1365-2125.2008.03311.x. Epub 2008 Sep 19. PMID: 19220279 Free PMC Article</br>4:Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. Yamada Y, Kato T, Ogino H, Ashina S, Kato K.Horm Metab Res. 2008 Aug;40(8):539-43. doi: 10.1055/s-2008-1076699. Epub 2008 May 21. PMID: 18500680 </br>5:Cetilistat, a new lipase inhibitor for the treatment of obesity. Padwal R.Curr Opin Investig Drugs. 2008 Apr;9(4):414-21. Review. PMID: 18393108 </br>6:Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Kopelman P, Bryson A, Hickling R, Rissanen A, Rossner S, Toubro S, Valensi P.Int J Obes (Lond). 2007 Mar;31(3):494-9. Epub 2006 Sep 5. PMID: 16953261 |
