Cetirizine-d8

• CAT Number: S000461
• CAS Number: 774596-22-4
• Molecular Formula: C21H17D8ClN2O3
• Molecular Weight: 396.94
• Purity: ≥95%
• IUPAC Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl]ethoxy]acetic acid;dihydrochloride
• InChI: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/i10D2,11D2,12D2,13D2
• InChIKey: PGLIUCLTXOYQMV-FLZNRFFQSA-N
• SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

Cetirizine-d8（Cat No.:S000461） is a deuterated version of cetirizine, where eight hydrogen atoms are replaced with deuterium, enhancing its metabolic stability for research purposes. Cetirizine is a second-generation antihistamine commonly used to treat allergic symptoms such as runny nose, sneezing, and itchy eyes. Unlike first-generation antihistamines, it typically does not cause drowsiness or anticholinergic effects. The deuterated version, Cetirizine-d8, is used in pharmacokinetic and metabolic studies to investigate how deuterium substitution affects the drug’s breakdown and elimination, providing insights into its duration of action and potential side effects.