Cetirizine Dihydrochloride

• CAT Number: A000267
• CAS Number: 83881-52-1
• Molecular Formula: C21H27Cl3N2O3
• Molecular Weight: 461.8
• Purity: ≥95%
• Synonyms: 83881-52-1; Zyrtec; Reactine; CETIRIZINE HYDROCHLORIDE; 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
• InChIKey: PGLIUCLTXOYQMV-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

Cetirizine hydrochloride (Cat.No:A000267) is a potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Cetirizine hydrochloride is a carboxylated metabolite of hydroxyzine that acts as a selective Histamine H1 receptor inverse agonist. Compared to its parent compound, it shows similar antihistaminic activity, but with greater H1 selectivity and less sedative effects.

Reference

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Characterization and taste masking evaluation of microparticles with cetirizine
dihydrochloride and methacrylate-based copolymer obtained by spray drying. Acta
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2: Sutar RS, Rathod VK. Ultrasound assisted enzyme catalyzed degradation of
Cetirizine dihydrochloride. Ultrason Sonochem. 2015 May;24:80-6. doi:
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3: Flórez Borges P, Pérez Lozano P, García Montoya E, Miñarro M, Ticó JR, Jo E,
Suñe Negre JM. Determination of stress-induced degradation products of cetirizine
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4: Goindi S, Kumar G, Kumar N, Kaur A. Development of novel elastic vesicle-based
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5: He S, Li F, Zhou D, Du J, Huang Y. Formulation and evaluation of novel coated
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6: Wei XL, Lei XR, Gong Q, Wang LS, Liao Y. [Determination of cetirizine
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7: Li FQ, Ji RR, Chen X, You BM, Pan YH, Su JC. Cetirizine dihydrochloride loaded
microparticles design using ionotropic cross-linked chitosan nanoparticles by
spray-drying method. Arch Pharm Res. 2010 Dec;33(12):1967-73. doi:
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8: Patil RH, Hegde RN, Nandibewoor ST. Electro-oxidation and determination of
antihistamine drug, cetirizine dihydrochloride at glassy carbon electrode
modified with multi-walled carbon nanotubes. Colloids Surf B Biointerfaces. 2011
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9: Subramanian S, Sankar V, Manakadan AA, Ismail S, Andhuvan G. Formulation and
evaluation of Cetirizine dihydrochloride orodispersible tablet. Pak J Pharm Sci.
2010 Apr;23(2):232-5. PubMed PMID: 20363705.

10: Kowalski P, Plenis A. Comparison of HPLC and CE methods for the determination
of cetirizine dihydrochloride in human plasma samples. Biomed Chromatogr. 2007
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