For research use only. Not for therapeutic Use.
Cetirizine, also known as AC-170, is a second-generation antihistamine used in the treatment of hay fever, allergies, angioedema, and urticaria. It is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist. Second-generation antihistamines like cetirizine are less able to cross the blood-brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs: for instance they are less likely to induce drowsiness or to interfere with memory formation.
| Catalog Number | I005982 |
| CAS Number | 83881-52-1 (HCl) |
| Synonyms | AC-170; AC 170; AC170; HSDB 7739; HSDB7739; HSDB-7739; Cetirizine; trade names Zirtec, Zyrtec, Reactine; Cetryn; Setir; Virlix; Ziptek.;2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride |
| Molecular Formula | C21H27Cl3N2O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride |
| InChI | InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H |
| InChIKey | PGLIUCLTXOYQMV-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl |
| Reference | </br>1:Effects of oral intake of cetirizine HCl and desloratadine molecules on the middle ear mucosa: an experimental animal study. Songu M, Ozkul Y, Kirtay S, Arslanoglu S, Ozkut M, Inan S, Onal K.Eur Arch Otorhinolaryngol. 2014 Apr;271(4):833-8. doi: 10.1007/s00405-014-2928-3. Epub 2014 Feb 14. PMID: 24526000 </br>2:Development and evaluation of cetirizine HCl taste-masked oral disintegrating tablets. Douroumis DD, Gryczke A, Schminke S.AAPS PharmSciTech. 2011 Mar;12(1):141-51. doi: 10.1208/s12249-010-9569-7. Epub 2010 Dec 23. PMID: 21181510 Free PMC Article</br>3:Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC. Arayne MS, Sultana N, Siddiqui FA.Pak J Pharm Sci. 2005 Jul;18(3):7-11. PMID: 16380337 </br>4:The health-related quality of life effects of once-daily cetirizine HCl in patients with seasonal allergic rhinitis: a randomized double-blind, placebo-controlled trial. Noonan MJ, Raphael GD, Nayak A, Greos L, Olufade AO, Leidy NK, Champan D, Kramer B.Clin Exp Allergy. 2003 Mar;33(3):351-8. PMID: 12614450 </br>5:The health-related quality of life effects of once-daily cetirizine HCl syrup in children with seasonal allergic rhinitis. Gillman SA, Blatter M, Condemi JJ, Collins M, Olufade AO, Leidy NK, Chapman D, Kramer B.Clin Pediatr (Phila). 2002 Nov-Dec;41(9):687-96. PMID: 12462319 |
