Cetrimide hydroxide

• CAT Number: I024409
• CAS Number: 505-86-2
• Molecular Formula: C19H43NO
• Molecular Weight: 301.56
• Purity: 98%
• Synonyms: Cetrimide; Cetyltrimethylammonium hydroxide; Cetrimide hydroxide
• Solubility: Soluble in DMSO
• Appearance: Liquid (10% wt in water)
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-Hexadecanaminium, N,N,N-trimethyl-, hydroxide
• InChI: InChI=1S/C19H42N.H2O/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H2/q+1;/p-1
• InChIKey: WJLUBOLDZCQZEV-UHFFFAOYSA-M
• SMILES: CCCCCCCCCCCCCCCC[N+](C)(C)C.[OH-]

Cetrimide is an antiseptic used to irrigate root canals to ensure disinfection and removal of microbial residues. Note: this product is being supplied as 10% wt in water.

Reference

1: María Ferrer-Luque C, Teresa Arias-Moliz M, Ruíz-Linares M, Elena Martínez García M, Baca P. Residual activity of cetrimide and chlorhexidine on Enterococcus faecalis-infected root canals. Int J Oral Sci. 2014 Mar;6(1):46-9. doi: 10.1038/ijos.2013.95. Epub 2013 Dec 20. PubMed PMID: 24357857; PubMed Central PMCID: PMC3967309.
2: Aydin C, Kayaalp C, Nessar G, Zengin N, Balkan M, Unal B, Ozgurtas T. Is cetrimide-chlorhexidine risky for secondary sclerosing cholangitis? Adv Clin Exp Med. 2014 May-Jun;23(3):395-8. PubMed PMID: 24979510.
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4: Engebretsen KA, Hald M, Johansen JD, Thyssen JP. Allergic contact dermatitis caused by an antiseptic containing cetrimide. Contact Dermatitis. 2015 Jan;72(1):60-1. doi: 10.1111/cod.12303. PubMed PMID: 25524123.
5: Ruiz-Linares M, Ferrer-Luque CM, Arias-Moliz T, de Castro P, Aguado B, Baca P. Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm. Ann Clin Microbiol Antimicrob. 2014 Aug 20;13:41. doi: 10.1186/s12941-014-0041-5. PubMed PMID: 25139679; PubMed Central PMCID: PMC4236523.
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14: Tripathy S, Sasmal P, Rao PB, Mishra TS, Nayak S. Cetrimide-chlorhexidine-induced multiorgan failure in surgery of pulmonary hydatid cyst. Ann Card Anaesth. 2016 Jul-Sep;19(3):557-60. doi: 10.4103/0971-9784.185565. PubMed PMID: 27397471; PubMed Central PMCID: PMC4971995.
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16: Deepalakshmi M, Poorni S, Miglani R, Rajamani I, Ramachandran S. Evaluation of the antibacterial and physical properties of glass ionomer cements containing chlorhexidine and cetrimide: an in-vitro study. Indian J Dent Res. 2010 Oct-Dec;21(4):552-6. doi: 10.4103/0970-9290.74217. PubMed PMID: 21187624.
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20: Vaddi HK, Wang LZ, Ho PC, Chan YW, Chan SY. Effect of cetrimide and ascorbic acid on in vitro human skin permeation of haloperidol. Chem Pharm Bull (Tokyo). 2001 Nov;49(11):1395-400. PubMed PMID: 11724228.