CFT8634

• CAT Number: I043847
• CAS Number: 2704617-96-7
• Molecular Formula: C37H45F3N6O5
• Molecular Weight: 710.79
• Purity: ≥95%
• Synonyms: (3R)-3-[4-[4-[(4S)-1-[[2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxopyridin-3-yl)phenyl]methyl]-3,3-difluoropiperidin-4-yl]piperazin-1-yl]-3-fluoroanilino]piperidine-2,6-dione
• IUPAC Name: (3S)-3-[4-[4-[(4S)-1-[[2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxopyridin-3-yl)phenyl]methyl]-3,3-difluoropiperidin-4-yl]piperazin-1-yl]-3-fluoroanilino]piperidine-2,6-dione
• InChI: InChI=1S/C37H45F3N6O5/c1-22-23(2)36(49)43(3)19-26(22)24-16-31(50-4)27(32(17-24)51-5)20-44-11-10-33(37(39,40)21-44)46-14-12-45(13-15-46)30-8-6-25(18-28(30)38)41-29-7-9-34(47)42-35(29)48/h6,8,16-19,29,33,41H,7,9-15,20-21H2,1-5H3,(H,42,47,48)/t29-,33-/m0/s1
• InChIKey: GNRGNRCQXHMQQV-ZQAZVOLISA-N
• SMILES: CC1=C(C(=O)N(C=C1C2=CC(=C(C(=C2)OC)CN3CC[C@@H](C(C3)(F)F)N4CCN(CC4)C5=C(C=C(C=C5)N[C@H]6CCC(=O)NC6=O)F)OC)C)C

CFT8634（Cat No.:I043847）is a selective inhibitor of the bromodomain and extra-terminal domain (BET) family of proteins, particularly targeting BRD9, a key component of the non-canonical BAF (BRG1-associated factor) chromatin remodeling complex. By inhibiting BRD9, CFT8634 disrupts the function of the BAF complex, which is implicated in various cancer-related processes such as tumor growth and metastasis. This compound shows potential in treating cancers with alterations in chromatin remodeling, especially in solid tumors and hematologic malignancies. CFT8634’s ability to modulate epigenetic pathways offers a novel strategy for cancer therapy.