For research use only. Not for therapeutic Use.
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1].
CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1].
| Catalog Number | I044689 |
| CAS Number | 2226970-01-8 |
| Synonyms | 4-amino-7-[[1-(2-fluorophenyl)pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile |
| Molecular Formula | C22H13F4N9 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H13F4N9/c23-14-3-1-2-4-15(14)35-10-12(6-33-35)9-34-16(5-27)17(18-19(28)31-11-32-20(18)34)13-7-29-21(30-8-13)22(24,25)26/h1-4,6-8,10-11H,9H2,(H2,28,31,32) |
| InChIKey | LSTMAJPRFFZYIT-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)N2C=C(C=N2)CN3C(=C(C4=C(N=CN=C43)N)C5=CN=C(N=C5)C(F)(F)F)C#N)F |
| Reference | [1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1 |
