For research use only. Not for therapeutic Use.
CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].
CFTR corrector 8 (compound 12) shows EC50s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay) [1].
CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat)[1].
| Catalog Number | I042763 |
| CAS Number | 1918142-35-4 |
| Synonyms | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2S,4S)-2-(3,4-dimethoxyphenyl)-7-methoxy-3,4-dihydro-2H-chromen-4-yl]cyclopropane-1-carboxamide |
| Molecular Formula | C29H27F2NO7 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H27F2NO7/c1-34-18-6-7-19-20(15-23(37-24(19)14-18)16-4-8-21(35-2)25(12-16)36-3)32-27(33)28(10-11-28)17-5-9-22-26(13-17)39-29(30,31)38-22/h4-9,12-14,20,23H,10-11,15H2,1-3H3,(H,32,33)/t20-,23-/m0/s1 |
| InChIKey | KDOQEEMQPHIANX-REWPJTCUSA-N |
| SMILES | COC1=CC2=C(C=C1)C(CC(O2)C3=CC(=C(C=C3)OC)OC)NC(=O)C4(CC4)C5=CC6=C(C=C5)OC(O6)(F)F |
| Reference | [1]. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. |
