For research use only. Not for therapeutic Use.
CFTR Inhibitor-172 is a small molecule compound that targets the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, specifically inhibiting its chloride ion channel function. This inhibitor has been studied for its potential to treat diseases associated with CFTR dysfunction, such as cystic fibrosis. CFTR Inhibitor-172 works by reducing CFTR channel activity, which can help in understanding CFTR-related pathophysiology and exploring therapeutic options for diseases caused by mutations or malfunctions in CFTR channels. It has shown promise in preclinical studies.
| Catalog Number | I003087 |
| CAS Number | 307510-92-5 |
| Synonyms | 4-[(E)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid |
| Molecular Formula | C₁₈H₁₀F₃NO₃S₂ |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20℃ |
| IC50 | 300 nM (Ki) |
| IUPAC Name | 4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid |
| InChI | InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8- |
| InChIKey | JIMHYXZZCWVCMI-ZSOIEALJSA-N |
| SMILES | C1=CC(=CC(=C1)N2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S)C(F)(F)F |
