cGAMP

• CAT Number: I005090
• CAS Number: 849214-04-6
• Molecular Formula: C20H24N10O13P2
• Molecular Weight: 674.4
• Purity: ≥95%
• Synonyms: Adenosine-Guanosine 3/’,3/’-cyclic monophosphate;c-GpAp;3/’,3/’-Cyclic GMP-AMP
• Target: STING
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChIKey: RFCBNSCSPXMEBK-INFSMZHSSA-N

Cyclic GMP-AMP (cGAMP)(CAT: I005090) is a second messenger molecule that plays an important role in the immune response to viral infections. It is produced by the enzyme cGAS (cyclic GMP-AMP synthase) when it detects the presence of foreign DNA, such as that from a virus. cGAMP then binds to the protein STING (stimulator of interferon genes), which triggers the production of type I interferons and other cytokines that help fight the infection. cGAMP has also been studied for its potential as an adjuvant in cancer immunotherapy, as it can stimulate the immune system to attack tumor cells.

Reference

[1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.
[2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150.
[3]. Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18.
[4]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.