For research use only. Not for therapeutic Use.
CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research[1].
CGP 25454A (0.5-10 μM, 15 min) elicits a reproducible and concentration-dependent increase of the release of both DA and ACh in rat striatal slices with an increase by 62±3% and 100±7% at 10 μM. CGP 25454A is 12.9 fold more potent at pre- than post-synaptic DA receptors[1].
CGP 25454A (10-100 mg/kg, i.p., 60 min) produces a marked, close-dependent increase in Spiperone binding in rat striatum[1].
CGP 25454A (0.5-100 mg/kg, i.p., 10-60 min) exerts opposite effects with a slight behavioral stimulation at low doses and a clear-cut central depressant action in the higher dose range[1].
| Catalog Number | I000250 |
| CAS Number | 104391-26-6 |
| Synonyms | 4-chloro-5-cyano-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride |
| Molecular Formula | C15H21Cl2N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H20ClN3O2.ClH/c1-4-19(5-2)7-6-18-15(20)12-8-11(10-17)13(16)9-14(12)21-3;/h8-9H,4-7H2,1-3H3,(H,18,20);1H |
| InChIKey | ZETCQNUMZFZSLJ-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCNC(=O)C1=C(C=C(C(=C1)C#N)Cl)OC.Cl |
| Reference | [1]. Bischoff S et al. CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist. |
