For research use only. Not for therapeutic Use.
Cgp 52608 (Cat.No:I006051) is selective ligand of the RAR-related orphan receptor alpha. CGP 52608 has also been reported to possess antiarthritic activity. Inquire Cgp 52608 online by filling out the inquiry form, we will get back to you within 24 hours!
| Catalog Number | I006051 |
| CAS Number | 87958-67-6 |
| Synonyms | Cgp 52608; Cgp52608; Cgp-52608.;Hydrazinecarbothioamide, N-methyl-2-(4-oxo-3-(2-propenyl)-2-thiazolidinylidene)- |
| Molecular Formula | C8H12N4OS2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at 4℃ |
| IUPAC Name | 1-methyl-3-[(E)-(4-oxo-3-prop-2-enyl-1,3-thiazolidin-2-ylidene)amino]thiourea |
| InChI | InChI=1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8+ |
| InChIKey | DDYJDIHOSRTMSE-DHZHZOJOSA-N |
| SMILES | CNC(=S)NN=C1N(C(=O)CS1)CC=C |
| Reference | </br>1:Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells. Winczyk K, Lawnicka H, Pawlikowski M, Kunert-Radek J, Karasek M.Neuro Endocrinol Lett. 2006 Jun;27(3):351-4. PMID: 16816834 </br>2:Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. Herrera F, Mayo JC, Martín V, Sainz RM, Antolin I, Rodriguez C.Cancer Lett. 2004 Jul 28;211(1):47-55. PMID: 15194216 </br>3:Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer. Winczyk K, Pawlikowski M, Karasek M.J Pineal Res. 2001 Sep;31(2):179-82. PMID: 11555175 </br>4:Antiproliferative effects of melatonin and CGP 52608. Karasek M, Pawlikowski M.Biol Signals Recept. 1999 Jan-Apr;8(1-2):75-8. PMID: 10085466 </br>5:Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608. Wiesenberg I, Chiesi M, Missbach M, Spanka C, Pignat W, Carlberg C.Mol Pharmacol. 1998 Jun;53(6):1131-8. PMID: 9614218 Free Article</br>6:CGP 52608-induced cyst formation in dinoflagellates: possible involvement of a nuclear receptor for melatonin. Tslm ST, Wong JT, Wong YH.J Pineal Res. 1996 Sep;21(2):101-7. PMID: 8912235 </br>7:Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Wiesenberg I, Missbach M, Kahlen JP, Schräder M, Carlberg C.Nucleic Acids Res. 1995 Feb 11;23(3):327-33. PMID: 7885826 Free PMC Article |
