For research use only. Not for therapeutic Use.
CGP 53716(CAT: I040708) is a potent, non-peptide antagonist of the neurokinin-1 (NK1) receptor, which binds the neuropeptide substance P. By blocking NK1 receptor activation, CGP 53716 is used to study the role of substance P in pain perception, inflammation, mood regulation, and neurogenic inflammation. It has been investigated in the context of central nervous system disorders, including anxiety, depression, and emesis. CGP 53716 is a valuable tool in pharmacological research for elucidating tachykinin receptor pathways and developing potential therapeutics targeting NK1-mediated signaling.
| CAS Number | 152459-94-4 |
| Synonyms | N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide |
| Molecular Formula | C23H19N5O |
| Purity | ≥95% |
| IUPAC Name | N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide |
| InChI | InChI=1S/C23H19N5O/c1-16-9-10-19(26-22(29)17-6-3-2-4-7-17)14-21(16)28-23-25-13-11-20(27-23)18-8-5-12-24-15-18/h2-15H,1H3,(H,26,29)(H,25,27,28) |
| InChIKey | UOEJSOXEHKCNAE-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=CC=C2)NC3=NC=CC(=N3)C4=CN=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
