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150175-54-5-CGP 55845 CGP 55845

CGP 55845

For research use only. Not for therapeutic Use.

  • CAT Number: I024468
  • CAS Number: 150175-54-5
  • Molecular Formula: C18H22Cl2NO3P
  • Molecular Weight: 402.25
  • Purity: 98%
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CGP 55845 is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively).


Catalog Number I024468
CAS Number 150175-54-5
Synonyms

CGP 55845; CGP-55845; CGP55845

Molecular Formula C18H22Cl2NO3P
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name Phosphinic acid, ((2S)-3-(((1S)-1-(3,4-dichlorophenyl)ethyl)amino)-2- hydroxypropyl)(phenylmethyl)-
InChI InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
InChIKey ZODSPDOOCZZEIM-BBRMVZONSA-N
SMILES O=P(CC1=CC=CC=C1)(C[C@@H](O)CN[C@H](C2=CC=C(Cl)C(Cl)=C2)C)O
Reference

1: Gillani Q, Ali M, Iqbal F. Effect of GABAB receptor antagonists (CGP 35348 and CGP 55845) on serum interleukin 6 and 18 concentrations in albino mice following neonatal hypoxia ischemia insult. Pak J Pharm Sci. 2016 Sep;29(5):1503-1508. PMID: 27731803.
2: Gillani QA, Akbar A, Ali M, Iqbal F. Gender-specific effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxia-ischemia insult. Neurol Sci. 2015 Jun;36(6):961-9. doi: 10.1007/s10072-015-2205-2. Epub 2015 Apr 7. PMID: 25847084.
3: Salah A, Perkins KL. Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. Neuropharmacology. 2008 Jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. Epub 2008 Apr 23. PMID: 18538357; PMCID: PMC2774743.
4: Lenina O, Petrov K, Kovyazina I, Malomouzh A. Enhancement of mouse diaphragm contractility in the presence of antagonists of GABAA and GABAB receptors. Exp Physiol. 2019 Jul;104(7):1004-1010. doi: 10.1113/EP087611. Epub 2019 May 27. PMID: 31074160.
5: Svejgaard B, Andreasen M, Nedergaard S. Role of GABAB receptors in proepileptic and antiepileptic effects of an applied electric field in rat hippocampus in vitro. Brain Res. 2019 May 1;1710:157-162. doi: 10.1016/j.brainres.2018.12.043. Epub 2018 Dec 29. PMID: 30599137.
6: Lang M, Moradi-Chameh H, Zahid T, Gane J, Wu C, Valiante T, Zhang L. Regulating hippocampal hyperexcitability through GABAB Receptors. Physiol Rep. 2014 Apr 22;2(4):e00278. doi: 10.14814/phy2.278. PMID: 24771688; PMCID: PMC4001873.
7: Salio C, Merighi A, Bardoni R. GABAB receptors-mediated tonic inhibition of glutamate release from Aβ fibers in rat laminae III/IV of the spinal cord dorsal horn. Mol Pain. 2017 Jan-Dec;13:1744806917710041. doi: 10.1177/1744806917710041. PMID: 28565998; PMCID: PMC5456036.
8: Luo F, Kiss ZH. Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus. J Neurophysiol. 2016 Jan 1;115(1):60-7. doi: 10.1152/jn.00269.2015. Epub 2015 Sep 2. PMID: 26334006; PMCID: PMC4760488.
9: Buonomano DV, Merzenich MM. Net interaction between different forms of short- term synaptic plasticity and slow-IPSPs in the hippocampus and auditory cortex. J Neurophysiol. 1998 Oct;80(4):1765-74. doi: 10.1152/jn.1998.80.4.1765. PMID: 9772237.
10: Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RWM, van Hulten JA, van Bakel NHM, Roosen J, van der Linden RJ, Schubert D, Verheij MMM, Kasri NN, Martens GJM. Increased GABAB receptor signaling in a rat model for schizophrenia. Sci Rep. 2016 Sep 30;6:34240. doi: 10.1038/srep34240. PMID: 27687783; PMCID: PMC5043235.

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