For research use only. Not for therapeutic Use.
CGP 57380（Cat No.:I013945）is a selective inhibitor of the ribosomal S6 kinase (RSK) family member p90 RSK, which is involved in the regulation of cell growth, survival, and proliferation. By inhibiting p90 RSK, CGP 57380 disrupts downstream signaling in the MAPK/ERK pathway, leading to reduced cell proliferation and survival. It is widely used in cancer research to study the role of p90 RSK in tumor growth and progression. CGP 57380 is valuable for exploring therapeutic strategies that target aberrant cell signaling in diseases such as cancer and neurodegenerative disorders.
| Catalog Number | I013945 |
| CAS Number | 522629-08-9 |
| Molecular Formula | C₁₁H₉FN₆ |
| Purity | ≥95% |
| Target | MNK |
| Solubility | DMSO: ≥ 43 mg/mL |
| IUPAC Name | 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
| InChI | InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) |
| InChIKey | UQPMANVRZYYQMD-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F |
| Reference | [1]. Knauf U, et al. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol Cell Biol. 2001 Aug;21(16):5500-11.<br>[2]. Ishida M, et al. Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ Res. 2003 Dec 12;93(12):1218-24. Epub 2003 Nov 6.<br><br>[3]. Chrestensen CA, et al. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells. 2007 Oct;12(10):1133-40.<br><br>[4]. Lim S, et al. Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307. |
