CGP60474

• CAT Number: I002155
• CAS Number: 164658-13-3
• Molecular Formula: C18H18ClN5O
• Molecular Weight: 355.82
• Purity: ≥95%
• Synonyms: 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
• Target: Cyclin-Dependent Kinases
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)
• InChIKey: IYNDTACKOAXKBJ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)Cl)NC2=NC=CC(=N2)C3=CC(=NC=C3)NCCCO

CGP60474（Cat No.:I002155）is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK1 and CDK2, which are key regulators of cell cycle progression. By inhibiting these kinases, CGP60474 prevents the phosphorylation of crucial proteins involved in the G1/S and G2/M transitions, leading to cell cycle arrest and apoptosis. It is widely used in cancer research to study CDK-driven tumor growth and evaluate potential therapeutic strategies targeting aberrant cell cycle regulation. CGP60474 has potential applications in cancer treatment, especially in tumors characterized by uncontrolled CDK activity.

Reference

[1]. Kuo GH, Deangelis A, Emanuel S, Wang A, Zhang Y, Connolly PJ, Chen X, Gruninger RH, Rugg C, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV.Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.J Med Chem. 2005 Jul 14;48(14):4535-46.
[2]. Stanetty P, Hattinger G, Schnürch M, Mihovilovic MD.Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy.J Org Chem. 2005 Jun 24;70(13):5215-20.