CGS-12066 maleate salt

• CAT Number: I006069
• CAS Number: 1350965-83-1
• Molecular Formula: C21H21F3N4O4
• Molecular Weight: 450.418
• Purity: ≥95%
• Synonyms: CGS-12066 maleate salt; CGS-12066; CGS -12066; CGS12066 .;7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo-[1,2-a]quinoxaline maleate salt
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: (E)-but-2-enedioic acid;4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
• InChI: InChI=1S/C17H17F3N4.C4H4O4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16;5-3(6)1-2-4(7)8/h2-6,11H,7-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: ZBPAHEUAJMCLRD-WLHGVMLRSA-N
• SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O

CGS-12066 maleate salt (CAT: I006069) is a compound that acts as an agonist for the 5-HT1B serotonin receptor. The 5-HT1B receptor is a subtype of serotonin (5-HT) receptors that plays a role in regulating neurotransmitter release, vasoconstriction, and other physiological processes. By selectively activating the 5-HT1B receptor, CGS-12066 maleate salt can modulate serotonin signaling and its downstream effects. This compound is commonly used in research to study the function and pharmacology of the 5-HT1B receptor and its potential role in various physiological and pathological conditions.

Reference

1: García-Pedraza JÁ, García M, Martín ML, Morán A. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascul Pharmacol. 2015 Sep;72:172-80. doi: 10.1016/j.vph.2015.05.003. PubMed PMID: 26003124.