CGS 21680 Hydrochloride

• CAT Number: I000969
• CAS Number: 124431-80-7
• Molecular Formula: C23H29N7O6 • HCl
• Molecular Weight: 536.00
• Purity: ≥95%
• Synonyms: 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride
• Target: Adenosine Receptor
• Solubility: DMSO: ≥ 20 mg/mL
• Storage: 2-8°C
• IC50: 22 nM
• InChI: InChI=1S/C23H29N7O6.ClH/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H/t16-,17+,18-,22+;/m0./s1
• InChIKey: QPHVMNOEKKJYJO-MJWSIIAUSA-N
• SMILES: CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O.Cl

CGS 21680 HCl（Cat No.:I000969）is a potent agonist of the adenosine A2 receptor. With an IC50 value of 22 nM, it demonstrates high affinity for the A2 receptor subtype. Importantly, CGS 21680 HCl exhibits a significant selectivity for the A2 receptor over the A1 receptor, with a 140-fold difference in potency. This selectivity is crucial for specific modulation of A2 receptor-mediated signaling pathways, enabling researchers to investigate the functional roles and therapeutic potential of the adenosine A2 receptor in various physiological and pathological conditions.

Reference

[1]. Hutchison AJ, et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther, 1989, 251(1), 47-55.
[2]. Jarvis MF, et al. [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J Pharmacol Exp Ther, 1989, 251(3), 888-893.
[3]. Phillis JW, et al. The selective adenosine A2 receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res, 1990, 509(2), 328-30.