CGS 35601

• CAT Number: I024500
• CAS Number: 849066-09-7
• Molecular Formula: C23H31N3O4S
• Molecular Weight: 445.57
• Purity: 98%
• Synonyms: CGS 35601; CGS-35601; CGS35601
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1-((S)-2-mercapto-4-methylpentanamido)cyclopentane-1-carbonyl)-L-tryptophan
• InChI: InChI=1S/C23H31N3O4S/c1-14(2)11-19(31)20(27)26-23(9-5-6-10-23)22(30)25-18(21(28)29)12-15-13-24-17-8-4-3-7-16(15)17/h3-4,7-8,13-14,18-19,24,31H,5-6,9-12H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)/t18-,19-/m0/s1
• InChIKey: YFAHICISBQLBQH-OALUTQOASA-N
• SMILES: O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C3(NC([C@@H](S)CC(C)C)=O)CCCC3)=O

CGS 35601(CAT: I024500) is a synthetic endothelin receptor antagonist, widely utilized in cardiovascular and renal research. It inhibits the activity of endothelin-1, a potent vasoconstrictor, by blocking its interaction with endothelin receptors. This compound is particularly valuable for studying the mechanisms underlying hypertension, pulmonary arterial hypertension (PAH), and kidney diseases. Researchers use CGS 35601 to explore its therapeutic potential in mitigating vascular dysfunction, reducing inflammation, and preventing tissue fibrosis. Its specificity and effectiveness make it an essential tool for preclinical studies aimed at developing targeted treatments for endothelin-related cardiovascular and renal conditions.