CH1055

• CAT Number: I043811
• CAS Number: 1622250-38-7
• Molecular Formula: C54H44N6O8S2
• Molecular Weight: 969.09
• Purity: ≥95%
• Synonyms: 3-[4-[4-(2-carboxyethyl)-N-[4-[8-[4-[4-(2-carboxyethyl)-N-[4-(2-carboxyethyl)phenyl]anilino]phenyl]-5λ4,11-dithia-4,6,10,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),2,4,5,7,9-hexaen-2-yl]phenyl]anilino]phenyl]propanoic acid
• IUPAC Name: 3-[4-[4-(2-carboxyethyl)-N-[4-[8-[4-[4-(2-carboxyethyl)-N-[4-(2-carboxyethyl)phenyl]anilino]phenyl]-5lambda4,11-dithia-4,6,10,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),2,4,5,7,9-hexaen-2-yl]phenyl]anilino]phenyl]propanoic acid
• InChI: InChI=1S/C54H44N6O8S2/c61-45(62)29-9-33-1-17-39(18-2-33)59(40-19-3-34(4-20-40)10-30-46(63)64)43-25-13-37(14-26-43)49-51-53(57-69-55-51)50(54-52(49)56-70-58-54)38-15-27-44(28-16-38)60(41-21-5-35(6-22-41)11-31-47(65)66)42-23-7-36(8-24-42)12-32-48(67)68/h1-8,13-28H,9-12,29-32H2,(H,61,62)(H,63,64)(H,65,66)(H,67,68)
• InChIKey: LTJDYGCWCCRPBZ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CCC(=O)O)N(C2=CC=C(C=C2)CCC(=O)O)C3=CC=C(C=C3)C4=C5C(=C(C6=NSN=C46)C7=CC=C(C=C7)N(C8=CC=C(C=C8)CCC(=O)O)C9=CC=C(C=C9)CCC(=O)O)N=S=N5

CH1055（Cat No.:I043811）is a selective inhibitor of the enzyme receptor tyrosine kinase, specifically targeting the vascular endothelial growth factor receptor 2 (VEGFR2). This receptor plays a pivotal role in angiogenesis, the process by which new blood vessels form from existing ones, a key event in tumor growth and metastasis. By inhibiting VEGFR2, CH1055 can reduce tumor vascularization, limiting tumor growth and spread. It shows promise as a therapeutic agent in cancer treatment, particularly in solid tumors, by targeting angiogenesis and enhancing the effectiveness of other anti-cancer therapies.