For research use only. Not for therapeutic Use.
CH7233163(CAT: I040800) is a potent, noncovalent, ATP-competitive inhibitor specifically targeting EGFR-Del19/T790M/C797S mutations. It effectively overcomes resistance to Osimertinib (HY-15772), a common challenge in EGFR-mutant non-small cell lung cancer (NSCLC) treatment. CH7233163 inhibits EGFR phosphorylation in Del19/T790M/C797S_NIH3T3 cells, demonstrating its ability to suppress aberrant EGFR signaling. By selectively targeting these triple-mutant EGFR variants, CH7233163 exhibits strong antitumor activity, making it a promising candidate for overcoming resistance mechanisms in cancer therapy. Its unique mechanism of action offers potential therapeutic benefits for patients with advanced or treatment-resistant EGFR-mutant cancers.
| CAS Number | 2923365-71-1 |
| Synonyms | N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-(2,2,2-trifluoroethoxy)pyrido[4,3-b]indol-3-amine |
| Molecular Formula | C31H34F3N9O3S |
| Purity | ≥95% |
| IUPAC Name | N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-(2,2,2-trifluoroethoxy)pyrido[4,3-b]indol-3-amine |
| InChI | InChI=1S/C31H34F3N9O3S/c1-19(2)43-24-14-28(38-27-6-7-35-30(39-27)20-15-37-42(17-20)47(44,45)22-4-5-22)36-16-23(24)29-25(43)12-21(41-10-8-40(3)9-11-41)13-26(29)46-18-31(32,33)34/h6-7,12-17,19,22H,4-5,8-11,18H2,1-3H3,(H,35,36,38,39) |
| InChIKey | KMBMYNDPNVGEFI-UHFFFAOYSA-N |
| SMILES | CC(C)N1C2=CC(=NC=C2C3=C1C=C(C=C3OCC(F)(F)F)N4CCN(CC4)C)NC5=NC(=NC=C5)C6=CN(N=C6)S(=O)(=O)C7CC7 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
