Chartreusin

• CAT Number: R001393
• CAS Number: 6377-18-0
• Molecular Formula: C32H32O14
• Molecular Weight: 640.594
• Purity: 99%
• Target: Bacterial
• Appearance: Yellow solid
• Storage: -20°C
• Analysis method: HPLC
• InChI: InChI=1S/C32H32O14/c1-10-8-9-15-18-16(10)29(38)45-26-17-13(23(35)20(19(18)26)30(39)43-15)6-5-7-14(17)44-32-28(24(36)21(33)11(2)42-32)46-31-25(37)27(40-4)22(34)12(3)41-31/h5-9,11-12,21-22,24-25,27-28,31-37H,1-4H3/t11-,12-,21+,22+,24+,25-,27+,28-,31-,32+/m1/s1
• InChIKey: PONPPNYZKHNPKZ-RYBWXQSLSA-N
• SMILES: CC1C(C(C(C(O1)OC2=CC=CC3=C2C4=C5C6=C(C=CC(=C6C(=O)O4)C)OC(=O)C5=C3O)OC7C(C(C(C(O7)C)O)OC)O)O)O

Chartreusin(cas 6377-18-0) is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It
inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent
inhibitor of topoisomerase II.

Reference

Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Leach, B.E. et al. , J.Am.Chem.Soc. 1953, 75, 4011. 

Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of topoisomerase II. Lorico A. and Long B.H. Eur. J. Cancer 1993, 14, 1985. 

Chartreusin, elsamicin A and related anti-cancer antibiotics. Portugal J. Curr. Med. Chem. Anticancer Agents. 2003, 3, 411.