CHARYBDOTOXIN (Native)

• CAT Number: P000021
• CAS Number: 95751-30-7
• Molecular Formula: C176H277N57O55S7
• Molecular Weight: 4295.95
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: Well in saline
• Storage: Desiccate at -20C
• SMILES: CC(C[C@@]1([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=NC(C(O)=NC(C(O)=N[C@@](C(O)=NC(C(O)=N[C@@](/C(O)=N[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CO)([H])CC2=CC=C(

CHARYBDOTOXIN (cas 95751-30-7) 37-amino acid peptide with 3 disulfide bridges, from Leiurus quinquestriatus scorpion venom


It is a blocker of large conductance Ca

Reference

– Schweitz H, Bidard JN, Maes P, Lazdunski M. Charybdotoxin is a new member of the K+ channel toxin family that includes dendrotoxin I and mast cell degranulating peptide. Biochemistry. 1989 Dec 12;28(25):9708-14.

– Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ, Garcia ML. Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A. 1988 May;85(10):3329-33.

– Sugg EE, Garcia ML, Reuben JP, Patchett AA, Kaczorowski GJ. Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channel. J Biol Chem. 1990 Nov 5;265(31):18745-8.

– Massefski W Jr, Redfield AG, Hare DR, Miller C. Molecular structure of charybdotoxin, a pore-directed inhibitor of potassium ion channels. Science. 1990 Aug 3;249(4968):521-4. Retraction in: Massefski W Jr, Redfield AG, Hare DR, Miller C. Science. 1991 May 3;252(5006):631.