Chebulinic acid

• CAT Number: I002441
• CAS Number: 18942-26-2
• Molecular Formula: C41H32O27
• Molecular Weight: 956.68
• Purity: ≥95%
• Target: TGF-beta/Smad
• Storage: Store at -20°C
• IUPAC Name: 2-[(4R,5S,7R,8R,11S,12S,13S,21S)-13,17,18-trihydroxy-2,10,14-trioxo-5,21-bis[(3,4,5-trihydroxybenzoyl)oxy]-7-[(3,4,5-trihydroxybenzoyl)oxymethyl]-3,6,9,15-tetraoxatetracyclo[10.7.1.14,8.016,20]henicosa-1(19),16(20),17-trien-11-yl]acetic acid
• InChI: 1S/C41H32O27/c42-15-1-10(2-16(43)26(15)51)35(56)62-9-22-31-33(66-36(57)11-3-17(44)27(52)18(45)4-11)34(41(63-22)68-37(58)12-5-19(46)28(53)20(47)6-12)67-38(59)13-7-21(48)29(54)32-25(13)24(30(55)40(61)65-32)14(8-23(49)50)39(60)64-31/h1-7,14,22,24,30-31,33-34,41-48,51-55H,8-9H2,(H,49,50)/t14-,22+,24-,30-,31+,33-,34+,41-/m0/s1
• InChIKey: YGVHOSGNOYKRIH-FJPMMHPYSA-N
• SMILES: C1=C(C=C(C(=C1O)O)O)C(=O)OC[C@@H]2[C@@H]3[C@@H]([C@H]([C@@H](O2)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C6=C5[C@H]([C@@H](C(=O)O3)CC(=O)O)[C@@H](C(=O)O6)O)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O

Chebulinic acid (Cat No.: I002441) is a natural hydrolyzable tannin found in Terminalia chebula, known for its diverse pharmacological properties. It exhibits strong antioxidant, anti-inflammatory, antiviral, and antidiabetic activities. Chebulinic acid has been studied for its ability to scavenge free radicals, inhibit pro-inflammatory cytokines, and modulate glucose metabolism. Its therapeutic potential extends to cardiovascular protection, cancer prevention, and neuroprotection. As a multifunctional bioactive compound, chebulinic acid is widely used in traditional medicine and is gaining attention in modern pharmacological and nutraceutical research.

Reference

[1]. Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47.

[2]. Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20

[3]. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11.