For research use only. Not for therapeutic Use.
Chiglitazar, also known as CS-038, is a potent and selective PPAR agonist potentially for the treatment of type 2 diabetes. Chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Chiglitazar showed transactivating activity in each PPARα, γ, and δ subtype and upregulated the expression of PPARα and/or PPARδ downstream genes involved in the key processes of lipid metabolism and thermogenesis. Comparable blood glucose lowering effect was observed between chiglitazar and rosiglitazone, but chiglitazar did not significantly increase the body weight in KKAy and fat pad weight in db/db mice.
| Catalog Number | I006094 |
| CAS Number | 743438-45-1 |
| Synonyms | CS-038; CS 038; CS038; Chiglitazar;O=C(O)[C@@H](NC1=CC=CC=C1C(C2=CC=C(F)C=C2)=O)CC3=CC=C(OCCN4C5=C(C6=C4C=CC=C6)C=CC=C5)C=C3 |
| Molecular Formula | C36H29FN2O4 |
| Purity | ≥95% |
| Target | PPAR agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | (2S)-3-[4-(2-carbazol-9-ylethoxy)phenyl]-2-[2-(4-fluorobenzoyl)anilino]propanoic acid |
| InChI | InChI=1S/C36H29FN2O4/c37-26-17-15-25(16-18-26)35(40)30-9-1-4-10-31(30)38-32(36(41)42)23-24-13-19-27(20-14-24)43-22-21-39-33-11-5-2-7-28(33)29-8-3-6-12-34(29)39/h1-20,32,38H,21-23H2,(H,41,42)/t32-/m0/s1 |
| InChIKey | QNLWMPLUWMWDMQ-YTTGMZPUSA-N |
| SMILES | C1=CC=C2C(=C1)C3=CC=CC=C3N2CCOC4=CC=C(C=C4)CC(C(=O)O)NC5=CC=CC=C5C(=O)C6=CC=C(C=C6)F |
| Reference | </br>1:In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. He BK, Ning ZQ, Li ZB, Shan S, Pan DS, Ko BC, Li PP, Shen ZF, Dou GF, Zhang BL, Lu XP, Gao Y.PPAR Res. 2012;2012:546548. doi: 10.1155/2012/546548. Epub 2012 Oct 22. PMID: 23150725 Free PMC Article</br>2:Determination of chiglitazar, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatography-tandem mass spectrometry. Chu NN, Li XN, Chen WL, Xu HR.Pharmazie. 2007 Nov;62(11):825-9. PMID: 18065097 </br>3:The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Li PP, Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF.Br J Pharmacol. 2006 Jul;148(5):610-8. Epub 2006 Jun 5. PMID: 16751799 Free PMC Article |
