Chiglitazar

• CAT Number: I006094
• CAS Number: 743438-45-1
• Molecular Formula: C36H29FN2O4
• Molecular Weight: 572.63
• Purity: ≥95%
• Synonyms: CS-038; CS 038; CS038; Chiglitazar;O=C(O)[C@@H](NC1=CC=CC=C1C(C2=CC=C(F)C=C2)=O)CC3=CC=C(OCCN4C5=C(C6=C4C=CC=C6)C=CC=C5)C=C3
• Target: Vitamin D Related/Nuclear Receptor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: (2S)-3-[4-(2-carbazol-9-ylethoxy)phenyl]-2-[2-(4-fluorobenzoyl)anilino]propanoic acid
• InChI: InChI=1S/C36H29FN2O4/c37-26-17-15-25(16-18-26)35(40)30-9-1-4-10-31(30)38-32(36(41)42)23-24-13-19-27(20-14-24)43-22-21-39-33-11-5-2-7-28(33)29-8-3-6-12-34(29)39/h1-20,32,38H,21-23H2,(H,41,42)/t32-/m0/s1
• InChIKey: QNLWMPLUWMWDMQ-YTTGMZPUSA-N
• SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3N2CCOC4=CC=C(C=C4)C[C@@H](C(=O)O)NC5=CC=CC=C5C(=O)C6=CC=C(C=C6)F

Chiglitazar（Cat No.:I006094）is a novel, multi-targeted synthetic compound being investigated for the treatment of type 2 diabetes and associated metabolic disorders. It is a dual peroxisome proliferator-activated receptor (PPAR) agonist, specifically targeting PPAR-alpha and PPAR-gamma receptors. By activating these receptors, chiglitazar helps regulate lipid and glucose metabolism, improving insulin sensitivity, reducing blood glucose levels, and promoting lipid clearance. Preclinical and clinical trials have shown its potential to enhance metabolic control in diabetic patients, offering a promising alternative to existing therapies. However, further studies are required to evaluate its long-term safety and efficacy.